Ferulic acid inhibits stress and cell death induced by Ab oligomers: improved delivery by solid lipid nanoparticles. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Ferulic acid inhibits stress and cell death induced by Ab oligomers: improved delivery by solid lipid nanoparticles. (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1080/10717540600739914 (literal)

Alternative label

• P. Picone, M.L. Bondì, G. Montana, A. Bruno, G. Pitarresi, G. Giammona, M. Di Carlo (2009)
  Ferulic acid inhibits stress and cell death induced by Ab oligomers: improved delivery by solid lipid nanoparticles.
  in Free radical research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• P. Picone, M.L. Bondì, G. Montana, A. Bruno, G. Pitarresi, G. Giammona, M. Di Carlo (literal)

Pagina inizio

• 1133 (literal)

Pagina fine

• 1145 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 43 (literal)

Rivista

• Free radical research (Rivista)

Note

• Scopus (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IBIM-CNR ISMN-CNR (literal)

Titolo

• Ferulic acid inhibits stress and cell death induced by Ab oligomers: improved delivery by solid lipid nanoparticles. (literal)

Abstract

• Oxidative stress and dysfunctional mitochondria are among the earliest events in AD, triggering neurodegeneration. The use of natural antioxidants could be a neuroprotective strategy for blocking cell death. Here, the antioxidant action of ferulic acid (FA) on different paths leading to degeneration of recombinant b-amyloid peptide (rAb42) treated cells was investigated. Further, to improve its delivery, a novel drug delivery system (DDS) was used. Solid lipid nanoparticles (SLNs), empty or containing ferulic acid (FA-SNL), were developed as DDS. The resulting particles had small colloidal size and highly negative surface charge in water. Using neuroblastoma cells and rAb42 oligomers, it was demonstrated that free and SLNs- loaded FA recover cell viability. FA treatment, in particular if loaded into SLNs, decreased ROS generation, restored mitochondrial membrane potential (Dcm) and reduced cytochrome c release and intrinsic pathway apoptosis activation. Further, FA modulated the expression of Peroxiredoxin, an anti-oxidative protein, and attenuated phosphorylation of ERK1/2 activated by Ab oligomers. (literal)

Prodotto di

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)

Autore CNR

• MARIA LUISA BONDI' (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Ferulic acid inhibits stress and cell death induced by Ab oligomers: improved delivery by solid lipid nanoparticles." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)

Autore CNR di

• MARIA LUISA BONDI' (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Free radical research (Rivista)

Insieme di parole chiave di

• Keywords of "Ferulic acid inhibits stress and cell death induced by Ab oligomers: improved delivery by solid lipid nanoparticles." (Insieme di parole chiave)