Solid lipid nanoparticles (SLNs) containing nimesulide: preparation, characterization and in cytotoxicity studies (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Solid lipid nanoparticles (SLNs) containing nimesulide: preparation, characterization and in cytotoxicity studies (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• M.L. Bondì, A. Azzolina, E.F. Craparo, G. Capuano, N. Lampiasi , G. Giammona and M. Cervello. (2009)
  Solid lipid nanoparticles (SLNs) containing nimesulide: preparation, characterization and in cytotoxicity studies
  in Current nanoscience (Print); Bentham Science Publishers Ltd., Sharjah (Emirati Arabi Uniti)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• M.L. Bondì, A. Azzolina, E.F. Craparo, G. Capuano, N. Lampiasi , G. Giammona and M. Cervello. (literal)

Pagina inizio

• 39 (literal)

Pagina fine

• 44 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Current nanoscience (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ISMN IBIM IBIM IBIM (literal)

Titolo

• Solid lipid nanoparticles (SLNs) containing nimesulide: preparation, characterization and in cytotoxicity studies (literal)

Abstract

• The prospect of improved cancer therapy using Solid Lipid Nanoparticles (SLNs) as drug delivery system is promising. Several obstacles frequently encountered with anticancer compounds, such as poor drug solubility, are overcome by delivering them using SLN. Moreover, the intravenous administration of drugs into SLNs can potentially enhance drug blood circulation time and improve drug performance by inducing accumulation into tumours by enhanced permeability and retention (EPR) effect. This paper deals with the development of SLN containing nimesulide, a non-steroidal anti-inflammatory drug with antitumour effect and low solubility in water. Here, SLNs carrying nimesulide were prepared and characterized, and the antiproliferative effect of drug-loaded SLN versus free drug on HT-29 and SW-480 cell lines was here evaluated. All the obtained systems possess colloidal size, ranging from 85 to 132 nm and negative zeta potential values. Moreover these systems show good loading capacity and drug release profile, and an in vitro antitumour activity comparable to free drug. (literal)

Editore

• Bentham Science Publishers Ltd. (Editore)

Prodotto di

• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)

Autore CNR

• NADIA LAMPIASI (Unità di personale interno)
• MARIA LUISA BONDI' (Unità di personale interno)
• MELCHIORRE CERVELLO (Persona)
• ANTONINA AZZOLINA (Persona)

Insieme di parole chiave

• Keywords of "Solid lipid nanoparticles (SLNs) containing nimesulide: preparation, characterization and in cytotoxicity studies" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MELCHIORRE CERVELLO (Persona)
• NADIA LAMPIASI (Unità di personale interno)
• ANTONINA AZZOLINA (Persona)
• MARIA LUISA BONDI' (Unità di personale interno)

Prodotto

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current nanoscience (Rivista)

Editore di

• Bentham Science Publishers Ltd. (Editore)

Insieme di parole chiave di

• Keywords of "Solid lipid nanoparticles (SLNs) containing nimesulide: preparation, characterization and in cytotoxicity studies" (Insieme di parole chiave)