Imaging and Detection of Single Molecule Recognition Events on Organic Semiconductor Surfaces (Articolo in rivista)

Type
Label
  • Imaging and Detection of Single Molecule Recognition Events on Organic Semiconductor Surfaces (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/nl802721g (literal)
Alternative label
  • J. Preiner (2); N. S. Losilla (1); NS, A. Ebner (2); P. Annibale (3); F. Biscarini (3); R. Garcia (1); P. Hinterdorfer (2) (2009)
    Imaging and Detection of Single Molecule Recognition Events on Organic Semiconductor Surfaces
    in Nano letters (Print); ACS, American chemical society, Washington, DC (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • J. Preiner (2); N. S. Losilla (1); NS, A. Ebner (2); P. Annibale (3); F. Biscarini (3); R. Garcia (1); P. Hinterdorfer (2) (literal)
Pagina inizio
  • 571 (literal)
Pagina fine
  • 575 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 9 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 5 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • (1)Instituto de Microelectrónica de Madrid, CSIC, Isaac Newton 8, 28760 Tres Cantos, Madrid, Spain (2)Christian Doppler Laboratory for Nanoscopic Methods in Biophysics, Institutte for Biophysics, Johannes Kepler University of Linz, A-4040 Linz, Austria (3)CNR-Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), Via P. Gobetti 101, I-40129 Bologna, Italy (literal)
Titolo
  • Imaging and Detection of Single Molecule Recognition Events on Organic Semiconductor Surfaces (literal)
Abstract
  • The combination of organic thin film transistors and biological molecules could open new approaches for the detection and measurement of properties of biological entities. To generate specific addressable binding sites on such substrates, it is necessary to determine how single biological molecules, capable of serving as such binding sites behave upon attachment to semiconductor surfaces. Here, we use a combination of high-resolution atomic force microscopy topographical imaging and single molecule force spectroscopy (TREC), to study the functionality of antibiotin antibodies upon adsorption on pentacene islands, using biotin-functionalized, magnetically coated AFM tips. The antibodies could be stably adsorbed on the pentacene, preserving their functionality of recognizing biotin over the whole observation time of more than one hour. We have resolved individual antigen binding sites on single antibodies for the first time. This highlights the resolution capacity of the technique. (literal)
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