The promotion of secondary structures in single-stranded DNA by drugs that bind to duplex DNA: an atomic force microscopy study (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The promotion of secondary structures in single-stranded DNA by drugs that bind to duplex DNA: an atomic force microscopy study (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1088/0957-4484/19/38/384016 (literal)

Alternative label

• J. Adamcik (1), F. Valle (2), G. Witz (1), K. Rechendorff (1), G. Dieter (1) (2008)
  The promotion of secondary structures in single-stranded DNA by drugs that bind to duplex DNA: an atomic force microscopy study
  in Nanotechnology (Bristol. Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• J. Adamcik (1), F. Valle (2), G. Witz (1), K. Rechendorff (1), G. Dieter (1) (literal)

Pagina inizio

• 384016 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 19 (literal)

Rivista

• Nanotechnology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (1) Laboratoire de Physique de la Matie`re Vivante, Ecole Polytechnique Fe ?de ?rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland (2) CNR-Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), Sezione di Bologna, Via P Gobetti 101, 40129 Bologna, Italy (literal)

Titolo

• The promotion of secondary structures in single-stranded DNA by drugs that bind to duplex DNA: an atomic force microscopy study (literal)

Abstract

• We study the behavior of single-stranded DNA (ssDNA) in the presence of well-known drugs with either an intercalating binding mode, such as daunorubicin, actinomycin D, and chloroquine, or a minor groove binding mode, such as netropsin and berenil, by atomic force microscopy (AFM). At very low salt conditions, ssDNA molecules adopt an unstructured conformation without secondary structures. We observe that under these conditions additions of drugs that bind to double-stranded DNA (dsDNA) promote the formation of secondary structures in ssDNA. Furthermore, with an increase of concentration of the drugs, the extension as well as the thermal stabilization of these hairpins was observed. (literal)

Prodotto di

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Nanotecnologie di materiali multifunzionali e sistemi biologici (PM.P05.010.001) (Modulo)

Autore CNR

• FRANCESCO VALLE (Unità di personale interno)

Incoming links:

Prodotto

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Nanotecnologie di materiali multifunzionali e sistemi biologici (PM.P05.010.001) (Modulo)

Autore CNR di

• FRANCESCO VALLE (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nanotechnology (Rivista)