Immunological study of IFNbeta-1a treated and untreated multiple sclerosis patients: clarifying IFNbeta mechanisms and establishing specific dendritic cell immunotherapy (Articolo in rivista)

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  • Immunological study of IFNbeta-1a treated and untreated multiple sclerosis patients: clarifying IFNbeta mechanisms and establishing specific dendritic cell immunotherapy (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1159/000082362 (literal)
Alternative label
  • BERGHELLA AM a; TOTARO R b; PELLEGRINI P a; CONTASTA I a; RUSSO T b; CAROLEI A b; ADORNO Da (2005)
    Immunological study of IFNbeta-1a treated and untreated multiple sclerosis patients: clarifying IFNbeta mechanisms and establishing specific dendritic cell immunotherapy
    in Neuroimmunomodulation (Basel); Karger, Paris (Francia)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • BERGHELLA AM a; TOTARO R b; PELLEGRINI P a; CONTASTA I a; RUSSO T b; CAROLEI A b; ADORNO Da (literal)
Pagina inizio
  • 29 (literal)
Pagina fine
  • 44 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Istituto CNR per i Trapianti d'Organo e l'Immunocitologia (ITOI) L'Aquila; b Dipartimento di Neurologia dell'Università dell'Aquila (literal)
Titolo
  • Immunological study of IFNbeta-1a treated and untreated multiple sclerosis patients: clarifying IFNbeta mechanisms and establishing specific dendritic cell immunotherapy (literal)
Abstract
  • Objectives: A comparative immunological evaluation of MS patients receiving IFN beta treatment and patients who are not, may help clarify IFN beta neurological mechanisms and lead the way to an effective Dentritic Cells (DCs) immunotherapy. This type of study helps clarify the pathological function, of T cells and DCs within the TH1/TH2/TH3 network as well as the specific interactions between TH1/TH2/TH3 cytokines implicated in MS pathological mechanisms and the best way of re-establishing TH1/TH2/TH3 network equilibrium. Methods: We studied network interactions between TH1/TH2TH3 cytokine levels in serum and supernatants of whole blood and CD14+ monocyte derived DCs in the remission phase of the disease and in correlation to the Expanded Disability Status Scale (EDSS). Results: We found that TH1 disregulation results in disruption of the maturation and activation of dendritic and T cells, and a lack of T-regulating cells (Trs) for the induction of self-tolerance; IFN beta mechanisms restore regulation by re-establishing the network balance but fail to resolve the disease completely due to in vivo IL12p70 network interactions leading to the deletion of self-aggressive cells. Conclusions: Our results indicate that a specific DC immunotherapy could cure rather than treat MS. The best point to re-establish the normal physiological cycle is at the immature (I)DC stage which can be done in vitro from treated peripheral blood CD14+ cell and used in vivo to stimulate the expansion of specific regulatory T cells. (literal)
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