http://www.cnr.it/ontology/cnr/individuo/prodotto/ID5336
PPARß agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y. (Articolo in rivista)
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- PPARß agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/jcp.20996 (literal)
- Alternative label
S. Di Loreto2; B. DAngelo1; M. DAmico1; E. Benedetti1;L. Cristiano1; B. Cinque3; M.G. Cifone3; M.P. Cerù1; C. Festuccia3; A. Cimini.1 (2007)
PPARß agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y.
in Journal of cellular physiology (Print); John Wiley & Sons Inc., Hoboken (Stati Uniti d'America)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- S. Di Loreto2; B. DAngelo1; M. DAmico1; E. Benedetti1;L. Cristiano1; B. Cinque3; M.G. Cifone3; M.P. Cerù1; C. Festuccia3; A. Cimini.1 (literal)
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- 1 Department of Basic and Applied Biology, University of L'Aquila, Italy;
2 ITOI, CNR, L'Aquila, Italy;
3 Department of Experimental Medicine, University of L'Aquila, Italy (literal)
- Titolo
- PPARß agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y. (literal)
- Abstract
- Neuroblastomas are pediatric tumors originating from immature neuroblasts in the developing peripheral nervous system. Differentiation
therapies could help lowering the high mortality due to rapid tumor progression to advanced stages. Oleic acid has been demonstrated to
promote neuronal differentiation in neuronal cultures. Herein we report on the effects of oleic acid and of a specific synthetic PPARb
agonist on cell growth, expression of differentiation markers and on parameters responsible for the malignancy such as adhesion,
migration, invasiveness, BDNF, and TrkB expression of SH-SY5Y neuroblastoma cells. The results obtained demonstrate that many, but
not all, oleic acid effects are mediated by PPARb and support a role for PPARb in neuronal differentiation strongly pointing towards PPAR
ligands as new therapeutic strategies against progression and recurrences of neuroblastoma. (literal)
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