PPARß agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• PPARß agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/jcp.20996 (literal)

Alternative label

• S. Di Loreto2; B. D’Angelo1; M. D’Amico1; E. Benedetti1;L. Cristiano1; B. Cinque3; M.G. Cifone3; M.P. Cerù1; C. Festuccia3; A. Cimini.1 (2007)
  PPARß agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y.
  in Journal of cellular physiology (Print); John Wiley & Sons Inc., Hoboken (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• S. Di Loreto2; B. D’Angelo1; M. D’Amico1; E. Benedetti1;L. Cristiano1; B. Cinque3; M.G. Cifone3; M.P. Cerù1; C. Festuccia3; A. Cimini.1 (literal)

Pagina inizio

• 837 (literal)

Pagina fine

• 847 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 211 (literal)

Rivista

• Journal of cellular physiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)
• PubMe (literal)
• Google Scholar (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Department of Basic and Applied Biology, University of L'Aquila, Italy; 2 ITOI, CNR, L'Aquila, Italy; 3 Department of Experimental Medicine, University of L'Aquila, Italy (literal)

Titolo

• PPARß agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y. (literal)

Abstract

• Neuroblastomas are pediatric tumors originating from immature neuroblasts in the developing peripheral nervous system. Differentiation therapies could help lowering the high mortality due to rapid tumor progression to advanced stages. Oleic acid has been demonstrated to promote neuronal differentiation in neuronal cultures. Herein we report on the effects of oleic acid and of a specific synthetic PPARb agonist on cell growth, expression of differentiation markers and on parameters responsible for the malignancy such as adhesion, migration, invasiveness, BDNF, and TrkB expression of SH-SY5Y neuroblastoma cells. The results obtained demonstrate that many, but not all, oleic acid effects are mediated by PPARb and support a role for PPARb in neuronal differentiation strongly pointing towards PPAR ligands as new therapeutic strategies against progression and recurrences of neuroblastoma. (literal)

Editore

• John Wiley & Sons Inc. (Editore)

Prodotto di

• Basi molecolari e fattori immunoregolatori in neuropatologie e neuroprotezione (ME.P02.022.001) (Modulo)

Autore CNR

• SILVIA DI LORETO (Persona)

Insieme di parole chiave

• Parole chiave di "PPARß agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• SILVIA DI LORETO (Persona)

Prodotto

• Basi molecolari e fattori immunoregolatori in neuropatologie e neuroprotezione (ME.P02.022.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of cellular physiology (Rivista)

Editore di

• John Wiley & Sons Inc. (Editore)

Insieme di parole chiave di

• Parole chiave di "PPARß agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y." (Insieme di parole chiave)