Renal allograft immune response is influenced by patient and donor cytokine genotypes. (Articolo in rivista)

Type
Label
  • Renal allograft immune response is influenced by patient and donor cytokine genotypes. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/i.transproceed.2007.05.035 (literal)
Alternative label
  • Canossi A; Piazza A; Poggi E; Ozzella G; Di Rocco M; Papola F; Iaria G; Adorno D. (2007)
    Renal allograft immune response is influenced by patient and donor cytokine genotypes.
    in Transplantation proceedings
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Canossi A; Piazza A; Poggi E; Ozzella G; Di Rocco M; Papola F; Iaria G; Adorno D. (literal)
Pagina inizio
  • 1805 (literal)
Pagina fine
  • 1812 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 39 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto CNR-ITOI, L'Aquila - Roma (literal)
Titolo
  • Renal allograft immune response is influenced by patient and donor cytokine genotypes. (literal)
Abstract
  • This study investigated the impact of specific cytokine genotypes on the incidence of acute rejection episodes (ARE), chronic graft dysfunction (CGD), and anti-HLA donor-specific antibody (DS-Ab) production in 86 renal transplant recipients and 70 cadaveric donors. A PCR-SSP method was performed for the analysis of polymorphisms in TNF-?, IL-6, TGF-?, IL-10, and IFN-? cytokines. DS-Ab monitoring of sera was performed using a FCXM analysis. Observed cytokine frequencies for patients and donors were not significantly different from the expected frequencies under Hardy-Weinberg equilibrium conditions. The evaluation in recipients revealed a higher frequency of DS-Ab-positive patients among the TNF-? high (50.0% vs 25.7%), and for the IL-10 cytokine a greater incidence of ARE-positive patients (35.8% vs 18.2%) with the high ? intermediate, compared with the low genotype. The combined effect of these 2 genotypes predisposed to DS-Abs (71.4% vs 25.3%; P ? 0.02; odds ratio [OR] ? 7.37). As for the TGF-?1 cytokine, we observed a higher number of CGD-positive patients among high compared with intermediate producers (14.3% vs 0%; P ? .050). The analysis of donors revealed a significantly lower incidence of ARE-positive patients among recipients whose donors were carriers of the high IL-6 G/G-genotype compared with the G/C?C/C-genotypes (16.7% vs 41.2%; P ? .03), suggesting a protective effect of the G/G genotype on ARE and a predisposing role of donor ?174allele C. In addition, we noted an association between the IFN-? low A/A-genotype and a higher incidence of ARE (42.1% vs 0%; P ? .002) and DS-Ab production (47.4% vs 12.5%; P ? .02) compared with high producers. (literal)
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