http://www.cnr.it/ontology/cnr/individuo/prodotto/ID53313
Photochemical outcome modification of diflunisal by a novel cationic amphiphilic cyclodextrin (Articolo in rivista)
- Type
- Label
- Photochemical outcome modification of diflunisal by a novel cationic amphiphilic cyclodextrin (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1039/b209157g (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Sortino S.; Petralia S.; Darcy R. and Donohue R. and Mazzaglia A (literal)
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- Rivista
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- pubblicazione scientifica (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento di Scienze Chimiche, Universita` degli Studi di Catania, Viale Andrea Doria 8,I-95125, Catania, Italy. b Centre for Synthesis and Chemical Biology of the Conway Institute, Department of Chemistry, National University of Ireland, University College Dublin, Belfield, Dublin 4, Ireland, Istituto per lo Studio dei Materiali Nanostrutturati (ISMN-CNR), Salita Sperone 31, I-98166, Messina, Italy, 98166, Messina, Italy (literal)
- Titolo
- Photochemical outcome modification of diflunisal by a novel cationic amphiphilic cyclodextrin (literal)
- Abstract
- The effects of a novel cationic amphiphilic cyclodextrin (SC6CDNH2) on the photoprocesses of the phototoxic non-steroidal anti-in.ammatory drug di.unisal (DF) have been investigated in aqueous medium. Association between DF and SC6CDNH2 was indicated by steady-state absorption, induced circular dichroism and fuorescence spectroscopy. Laser .ash photolysis and steady-state photolysis experiments revealed a particular sensitivity of the DF photochemistry to the new microenvironment. Reduction of the triplet state generation efficiency, lengthening of its lifetime, changes in the photoionisation pathways, besides remarkable drug photostabilization and modi.cation of the stable photoproducts distribution, were observed. A rationale for these modi.cations to the photochemistry of DF based on the multifaceted role of SC6CDNH2 in influencing the efficiency of the primary photochemical act and in interfering with secondary radical reactions is proposed.
Relation of the overall results to the phototoxic effects displayed by the drug is also commented upon. (literal)
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