On the reproducibility of results of pathway analysis in genome-wide expression studies of colorectal cancers (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• On the reproducibility of results of pathway analysis in genome-wide expression studies of colorectal cancers (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• R. Maglietta(a), A. Distaso(a), A. Piepoli(b), O. Palumbo(c), M. Carella(c), A. D’Addabbo(a), S. Mukherjee(d), N. Ancona(a) (2010)
  On the reproducibility of results of pathway analysis in genome-wide expression studies of colorectal cancers
  in Journal of biomedical informatics
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• R. Maglietta(a), A. Distaso(a), A. Piepoli(b), O. Palumbo(c), M. Carella(c), A. D’Addabbo(a), S. Mukherjee(d), N. Ancona(a) (literal)

Pagina inizio

• 397 (literal)

Pagina fine

• 397-40 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Q2 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 43 (literal)

Rivista

• Journal of biomedical informatics (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Istituto di Studi sui Sistemi Intelligenti per l'Automazione, CNR, Via Amendola 122/D-I, Bari, Italy b Unità Operativa di Gastroenterologia, IRCCS, ''Casa Sollievo della Sofferenza\"-Ospedale, 71013 San Giovanni Rotondo (FG), Italy c Servizio di Genetica Medica, IRCCS, ''Casa Sollievo della Sofferenza\"-Ospedale, 71013 San Giovanni Rotondo (FG), Italy d Institute for Genome Science and Policy, Duke University, Durham, NC, USA (literal)

Titolo

• On the reproducibility of results of pathway analysis in genome-wide expression studies of colorectal cancers (literal)

Abstract

• One of the major problems in genomics and medicine is the identification of gene networks and pathways deregulated in complex and polygenic diseases, like cancer. In this paper, we address the problem of assessing the variability of results of pathways analysis identified in different and independent genome wide expression studies, in which the same phenotypic conditions are assayed. To this end, we assessed the deregulation of 1891 curated gene sets in four independent gene expression data sets of subjects affected by colorectal cancer (CRC). In this comparison we used two well-founded statistical models for evaluating deregulation of gene networks. We found that the results of pathway analysis in expression studies are highly reproducible. Our study revealed 53 pathways identified by the two methods in all the four data sets analyzed with high statistical significance and strong biological relevance with the pathology examined. This set of pathways associated to single markers as well as to whole biological processes altered constitutes a signature of the disease which sheds light on the genetics bases of CRC. (literal)

Prodotto di

• Sistemi Sensoriali per il Controllo di Qualità e Diagnostica (SP.P03.002.001) (Modulo)
• Institute of intelligent systems for automation (ISSIA) (Istituto)

Autore CNR

• NICOLA ANCONA (Unità di personale interno)
• ANNARITA D'ADDABBO (Unità di personale esterno)
• ROSALIA MAGLIETTA (Persona)

Incoming links:

Prodotto

• Institute of intelligent systems for automation (ISSIA) (Istituto)
• Sistemi Sensoriali per il Controllo di Qualità e Diagnostica (SP.P03.002.001) (Modulo)

Autore CNR di

• NICOLA ANCONA (Unità di personale interno)
• ROSALIA MAGLIETTA (Persona)
• ANNARITA D'ADDABBO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of biomedical informatics (Rivista)