Automatic detection of roles of genetic markers in Crohn's disease by linear combinations of SNPs (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Automatic detection of roles of genetic markers in Crohn's disease by linear combinations of SNPs (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• A. D'Addabbo, A. Latiano, O. Palmieri, M.T. Creanza, R. Maglietta, V. Annese, N. Ancona (2008)
  Automatic detection of roles of genetic markers in Crohn's disease by linear combinations of SNPs
  in Artificial intelligence in medicine (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• A. D'Addabbo, A. Latiano, O. Palmieri, M.T. Creanza, R. Maglietta, V. Annese, N. Ancona (literal)

Rivista

• Artificial intelligence in medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• in press doi:10.1016/j.artmed.2008.07.012 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Istituto di Studi sui Sistemi Intelligenti per l’Automazione-C.N.R., Via Amendola 122/D-I, 70126 Bari, Italy b Unita` Operative di Gastroenterologia ed Endoscopia Digestiva, Ospedale IRCCS, ‘‘Casa Sollievo della Sofferenza’’, Viale Cappuccini, 71013 San Giovanni Rotondo (FG), Italy (literal)

Titolo

• Automatic detection of roles of genetic markers in Crohn's disease by linear combinations of SNPs (literal)

Abstract

• polymorphisms; Motivations: A large number of single nucleotide polymorphisms (SNPs) are supposed to be involved in onset, differentiation and development of complex diseases. Univariate analysis is limited in studying complex traits since does not take into account gene—gene interaction, and the correlation of multiple SNPs with a specific phenotype. Moreover it might underestimate gene variants with weaker genetic contribution. Therefore more sophisticated techniques should be adopted when investigating the role of a panel of genetic markers in disease predisposition. Methods: In this paper we describe a general method to simultaneously investigate the association between SNPs profile and Crohn’s disease (CD), by evaluating the susceptibility or protective role of single or groups of markers. As an association measure we adopted a weighted linear combination of SNPs in which suitable weighting vectors belonged to predefined and over-complete vocabularies of vectors (frames), or were determined by the data. (literal)

Prodotto di

• Institute of intelligent systems for automation (ISSIA) (Istituto)
• Sistemi Sensoriali per il Controllo di Qualità e Diagnostica (SP.P03.002.001) (Modulo)

Autore CNR

• ANNARITA D'ADDABBO (Unità di personale esterno)
• ROSALIA MAGLIETTA (Persona)
• NICOLA ANCONA (Unità di personale interno)

Incoming links:

Prodotto

• Institute of intelligent systems for automation (ISSIA) (Istituto)
• Sistemi Sensoriali per il Controllo di Qualità e Diagnostica (SP.P03.002.001) (Modulo)

Autore CNR di

• NICOLA ANCONA (Unità di personale interno)
• ROSALIA MAGLIETTA (Persona)
• ANNARITA D'ADDABBO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Artificial intelligence in medicine (Rivista)