Influence of chitosan glutamate on the in vivo intranasal absorption of rokitamycin from microspheres (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Influence of chitosan glutamate on the in vivo intranasal absorption of rokitamycin from microspheres (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Gavini E., Rassu G., Ferraro L., Generosi A., Rau J.V., Brunetti A., Giunchedi P., Dalpiaz A. (2011)
  Influence of chitosan glutamate on the in vivo intranasal absorption of rokitamycin from microspheres
  in Journal of pharmaceutical sciences
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gavini E., Rassu G., Ferraro L., Generosi A., Rau J.V., Brunetti A., Giunchedi P., Dalpiaz A. (literal)

Pagina inizio

• 1488 (literal)

Pagina fine

• 1502 (literal)

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• 100 (literal)

Rivista

• Journal of pharmaceutical sciences (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• http://dx.doi.org/10.1002/jps.22382 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Drug Sciences, University of Sassari, Sassari 07100, Italy Department of Experimental and Clinical Medicine, University of Ferrara, Ferrara 44100, Italy Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche, Rome 00133, Italy Struttura Dipartimentale di Matematica e Fisica, University of Sassari, Sassari, Italy Department of Pharmaceutical Sciences, University of Ferrara, Ferrara 44100, Italy (literal)

Titolo

• Influence of chitosan glutamate on the in vivo intranasal absorption of rokitamycin from microspheres (literal)

Abstract

• Intranasal delivery is an alternative method to target therapeutics to the central nervous system. In the present study, chitosan glutamate (CG)-based mucoadhesive microspheres containing rokitamycin (RK) were prepared by spray-drying and in vitro characterization. Moreover, the influence of CG on RK absorption in bloodstream and cerebrospinal fluid (CSF) was evaluated after nasal administration to rats. The in vivo results were compared with those obtained after nasal administration of chitosan (CH)-based microparticles containing RK and after intravenous (IV) administration of the free drug. The in vitro results indicate that the concentrations of feed solution or kind of CH influence the RK entrapment and size of microspheres. All formulations increase the solubility of this poorly water-soluble drug, but CG is more able to increase the in vitro dissolution rate of RK than CH. CG microspheres absorb water quickly and then dissolve, whereas CH particles need more volume of water for swelling and gelling. In vivo studies showed that, after IV administration, RK is not able to cross the blood–brain barrier and to reach the CSF from the bloodstream. On the contrary, drug goes to the CSF and the bloodstream only after nasal administration of CG microparticles. (literal)

Prodotto di

• Fotonica a raggi X (MD.P03.006.001) (Modulo)
• Institute of structure of matter (ISM) (Istituto)

Autore CNR

• AMANDA GENEROSI (Unità di personale interno)
• DZHULIETTA RAU (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of structure of matter (ISM) (Istituto)
• Fotonica a raggi X (MD.P03.006.001) (Modulo)

Autore CNR di

• DZHULIETTA RAU (Unità di personale esterno)
• AMANDA GENEROSI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of pharmaceutical sciences (Rivista)