http://www.cnr.it/ontology/cnr/individuo/prodotto/ID52424
The how, when, and why of the aging signals appearing on the human erythrocyte membrane: an atomic force microscopy study of surface roughness (Articolo in rivista)
- Type
- Label
- The how, when, and why of the aging signals appearing on the human erythrocyte membrane: an atomic force microscopy study of surface roughness (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.nano.2010.06.004 (literal)
- Alternative label
Girasole M. (1); Pompeo G. (1); Cricenti A. (1); Longo G. (1); Boumis G. (2); Bellelli A. (2); Amiconi S. (3) (2010)
The how, when, and why of the aging signals appearing on the human erythrocyte membrane: an atomic force microscopy study of surface roughness
in Nanomedicine (Lond., Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Girasole M. (1); Pompeo G. (1); Cricenti A. (1); Longo G. (1); Boumis G. (2); Bellelli A. (2); Amiconi S. (3) (literal)
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- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- http://dx.doi.org/10.1016/j.nano.2010.06.004 (literal)
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- (1) Istituto di Struttura della Materia CNR, Rome, Italy
(2) Dipartimento di Scienze Biochimiche A. Rossi-Fanelli - Università La Sapienza, Rome, Italy
(3) Klinik für Anästhesiologie, Operative Intensivmedizin und Schmerztherapie Krankenhaus München-Schwabing, München, Germany (literal)
- Titolo
- The how, when, and why of the aging signals appearing on the human erythrocyte membrane: an atomic force microscopy study of surface roughness (literal)
- Abstract
- We recently developed an atomic force microscopybased protocol to use the roughness of the plasma membrane of erythrocytes (red blood cells, RBCs) as a morphological parameter, independently from the cell shape, to investigate the membrane-skeleton integrity in healthy and pathological cells. Here we apply the method to investigate a complex physiological phenomenon, the RBCs aging, that plays a major role in the regulation of the RBCs' turnover. The aging, monitored morphologically and biochemically, has been accelerated and modulated by preventing oxidative stresses as well as the effects of proteases and divalent cations, and by artificially consuming the intracellular adenosine triphosphate. The collected data evidence that the progression of aging causes a drastic decrease of the measured roughness that is diagnostic of a progressive, adenosine triphosphatedependent alteration of the membrane-skeleton properties. Finally, the degree of reversibility of such effects has been investigated as a function of aging time, enabling the detection of irreversible transformation in the RBCs' structure and metabolism. (literal)
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