http://www.cnr.it/ontology/cnr/individuo/prodotto/ID5232
Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro (Articolo in rivista)
- Type
- Label
- Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- LAURA RONCUZZI 1,2; GIANPIERO MARTI 1; DANIELA BAIOCCHI 1;
ROSALBA DEL COCO 3; STEFANIA COCCHI 1; ANNA GASPERI-CAMPANI1 4 (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126 Bologna;
2Laboratorio di Fisiopatologia degli Impianti Ortopedici,
3ITOI sezione di Bologna c/o Laboratory of Cell Biology and Electron Microscopy,Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 40136 Bologna; 4Interdepartmental Center for the Research on Cancer, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy (literal)
- Titolo
- Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro (literal)
- Abstract
- Abstract. Vinorelbine (VNR) is a semi-synthetic vinca alkaloid known to exert its antitumour activity by interfering with the polymerisation of tubulin. It has shown a broad spectrum of activity in some advanced carcinomas of lung, breast and ovary. This report demonstrates for the first time the antiproliferative effect of VNR and its molecular mechanism in human osteosarcoma in vitro. TP53 wild-type HOS cells and TP53 mutated MG-63 cells were chosen for this study. In each cell line, VNR caused a significant dose- and time-dependent growth inhibition and induced apoptotic death independent of TP53 status. Phosphorylation and/or alteration of Bcl-2 were not induced by VNR, thereby indicating a new pathway utilised by the drug to induce apoptosis in this tumour in vitro. VNR produced a down-regulation of cyclin D1 and an upregulation of p53 expression in TP53 wild-type HOS cells, whereas no alteration in cyclin D1 expression was evident in the TP53 negative MG-63 cells. These data suggest a new
potential use for Vinorelbine as a therapeutic agent against human osteosarcoma. (literal)
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