Public epitope specificity of HLA class I antibodies induced by a failed kidney transplant: alloantibody characterization by flow citometric techniques. (Articolo in rivista)

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Label
  • Public epitope specificity of HLA class I antibodies induced by a failed kidney transplant: alloantibody characterization by flow citometric techniques. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1097/01.tp.0000209654.87584.c5 (literal)
Alternative label
  • Antonina Piazza (1); Elvira Poggi (1); Giuseppina Ozzella (1); Laura Borrelli (2); Palmina I. Monaco (1); Alessandra Scornajenghi (2); Giuseppe Tisone (2); Domenico Adorno (2) (2006)
    Public epitope specificity of HLA class I antibodies induced by a failed kidney transplant: alloantibody characterization by flow citometric techniques.
    in Transplantation
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Antonina Piazza (1); Elvira Poggi (1); Giuseppina Ozzella (1); Laura Borrelli (2); Palmina I. Monaco (1); Alessandra Scornajenghi (2); Giuseppe Tisone (2); Domenico Adorno (2) (literal)
Pagina inizio
  • 1298 (literal)
Pagina fine
  • 1305 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 81 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 9 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • (1) National Council of Research, Institute of Organ Transplantation and Immunocytology, Rome, Italy; (2) Department of Surgery, \"Tor Vergata\" University, Rome, Italy; (literal)
Titolo
  • Public epitope specificity of HLA class I antibodies induced by a failed kidney transplant: alloantibody characterization by flow citometric techniques. (literal)
Abstract
  • Background. Patients whose kidney grafts fail develop alloantibodies that react with many HLA molecules. We analyzed the epitope specificity of HLA class I alloantibodies detected in the sera of 55 patients who had been sensitized by kidney grafts, and investigated the immunogenicity of various polymorphic epitopes. Methods. HLA class I alloantibodies were detected and characterized by flow cytometric technique (FlowPRA beads). Potential \"immunizing epitopes\" were identified by comparing the amino acid sequences of HLA class I antigens/alleles of the donor, recipient and the antibody-reactivity pattern. Results: In the 55 anti-HLA class I-positive patients, 82 different antibody reactivity patterns were identified; all but 5 (94%) were due to recognition of a \"public epitope\" of donor HLA-A and/or -B molecules. Forty-five of the 50 patients who showed HLA-A Res-MMs with their donors produced HLA-A antibodies, but only 31 of the 51 subjects with HLA-B Res-MMs produced HLA-B antibodies (P = 0.001; O.R. = 5.81). The antibody patterns were specific for a \"single\" epitope of the mismatched donor molecules in 91% of patients. Forty-three of the 120 (36%) mismatched HLA-A and/or -B epitopes were positively correlated with antibody production. The polymorphic determinants of higher immunogenic capacity were b80N (Bw6-associated) and ab82-83LR (Bw4-associated) public epitopes. Conclusions. The humoral immune response against a kidney graft mainly produces HLA class I antibodies specific for \"public epitopes\" of mismatched donor molecules. A \"single\" donor-epitope may determine the production of a spread antibody pattern. In renal transplantation, epitope matching is better than HLA antigen matching for avoiding or minimizing development of HLA antibodies. (literal)
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