http://www.cnr.it/ontology/cnr/individuo/prodotto/ID5181
Peripheral blood immunological parameters for use as markers of pre-invasive to invasive colorectal cancer (Articolo in rivista)
- Type
- Label
- Peripheral blood immunological parameters for use as markers of pre-invasive to invasive colorectal cancer (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Berghella AM., Contasta I., Pellegrini P., Del Beato T., Adorno D. (2002)
Peripheral blood immunological parameters for use as markers of pre-invasive to invasive colorectal cancer
in Cancer biotherapy & radiopharmaceuticals
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Berghella AM., Contasta I., Pellegrini P., Del Beato T., Adorno D. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- L'obiettivo di questo lavoro è l'identificazione di eventuali marker utili per una diagnosi precoce (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
- In cancer, the extent to which the disease has spread
is probably the most important factor in determining
patient prognosis. Hence practical and non-invasive
methods are needed to identify disease stage. In a
previous paper we showed how diagnostic and prognostic
indices for disease progression could be defined by
evaluating parameters in peripheral blood. The aim of
this study was to identify further serum parameters
that could be used. Serum levels of interferon-gamma,
IL4, IL8, IL7, IL1b, TNFalfa, GM-CSF, sIL2R and sIL6R
were studied but only levels of IL4, sIL2R, IL8 and IL7
were found to be significant and would therefore of use
in defining diagnostic and prognostic indices for
disease progression. In further detail, our results
indicate that when serum levels of sIL2R<522 U/ml, IL4
<159pg/ml and IL8>339 pg/ml there is a 95% probability
that the disease is in stage I or II where there is no
infiltration of lymph nodes; when serum levels of
sIL2R>522 U/ml, 159pg/ml431pg/ml and
IL7>54 pg/ml, there is a 95% probability that the
disease is in stage IV and there is metastasis.
(literal)
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- ISTITUTO PER I TRAPIANTI D'ORGANO E L'IMMUNOCITOLOGIA (literal)
- Titolo
- Peripheral blood immunological parameters for use as markers of pre-invasive to invasive colorectal cancer (literal)
- Abstract
- In cancer, the extent to which the disease has spread
is probably the most important factor in determining
patient prognosis. Hence practical and non-invasive
methods are needed to identify disease stage. In a
previous paper we showed how diagnostic and prognostic
indices for disease progression could be defined by
evaluating parameters in peripheral blood. The aim of
this study was to identify further serum parameters
that could be used. Serum levels of interferon-gamma,
IL4, IL8, IL7, IL1b, TNFalfa, GM-CSF, sIL2R and sIL6R
were studied but only levels of IL4, sIL2R, IL8 and IL7
were found to be significant and would therefore of use
in defining diagnostic and prognostic indices for
disease progression. In further detail, our results
indicate that when serum levels of sIL2R<522 U/ml, IL4
<159pg/ml and IL8>339 pg/ml there is a 95% probability
that the disease is in stage I or II where there is no
infiltration of lymph nodes; when serum levels of
sIL2R>522 U/ml, 159pg/ml431pg/ml and
IL7>54 pg/ml, there is a 95% probability that the
disease is in stage IV and there is metastasis. (literal)
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