Apolipoprotein A-I-dependent cholesterol esterification in patients with rheumatoid arthritis. (Articolo in rivista)

Type
Label
  • Apolipoprotein A-I-dependent cholesterol esterification in patients with rheumatoid arthritis. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.lfs.2004.12.023 (literal)
Alternative label
  • Cigliano L., Spagnuolo M.S., Cuomo G., Valentini G., Niglio A., Abrescia P. (2005)
    Apolipoprotein A-I-dependent cholesterol esterification in patients with rheumatoid arthritis.
    in Life sciences (1973)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cigliano L., Spagnuolo M.S., Cuomo G., Valentini G., Niglio A., Abrescia P. (literal)
Pagina inizio
  • 108 (literal)
Pagina fine
  • 120 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 77 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 13 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Cigliano L; Abrescia P. Dipartimento delle Scienze Biologiche, Università di Napoli Federico II Cuomo G.; Valentini G. Dipartimento di Internistica Clinica e Sperimentale \"F. Magrassi\" - Unità di Reumatologia, Seconda Università di Napoli Niglio A. Dipartimento di Gerontologia, Geriatria e Malattie del Metabolismo. Seconda Università di Napoli. (literal)
Titolo
  • Apolipoprotein A-I-dependent cholesterol esterification in patients with rheumatoid arthritis. (literal)
Abstract
  • Growing evidence suggests that atherogenesis is associated with inflammation or defective removal of cholesterol excess from peripheral cells. Apolipoprotein A-I [ApoA-I] activates the enzyme Lecithin-Cholesterol Acyl-Transferase to esterify cell cholesterol for transport to liver. Haptoglobin [Hpt] was previously found able to bind ApoA-I, and suggested to reduce the enzyme activation. The aim of this study was to demonstrate that enhanced levels of Hpt, as present during inflammation, are associated with low enzyme activity and increased thickness of the arterial wall. Enzyme activity and Hpt concentration were analysed in patients with rheumatoid arthritis having the same plasma levels of antioxidants (ascorbate, urate, alpha-tocopherol, retinol) or oxidation markers (nitrotyrosine, lipoperoxide) of healthy subjects. Cholesterol esterification, determined as ratio of cholesteryl esters with cholesterol in high-density lipoproteins, was lower in patients than in controls, and negatively correlated with the intima-media wall thickness of the common carotid. The ratio of Hpt with ApoA-I was negatively correlated with the enzyme activity, while positively correlated with intima-media wall thickness. The results suggest that high Hpt levels might severely impair the enzyme activity, thus contributing to cholesterol accumulation in vascular cells, and lesion formation in the endothelium. (literal)
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