A proteomic study on human osteoblastic cells proliferation and differentiation (Articolo in rivista)

Type
Label
  • A proteomic study on human osteoblastic cells proliferation and differentiation (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Spreafico A, Frediani B, Capperucci C, Chellini F, Paffetti A, D'Ambrosio C, Bernardini G., Mini R, Collodel G, Scaloni A, Marcolongo R, Santucci A (2006)
    A proteomic study on human osteoblastic cells proliferation and differentiation
    in Proteomics (Weinh., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Spreafico A, Frediani B, Capperucci C, Chellini F, Paffetti A, D'Ambrosio C, Bernardini G., Mini R, Collodel G, Scaloni A, Marcolongo R, Santucci A (literal)
Pagina inizio
  • 3520 (literal)
Pagina fine
  • 3532 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 6 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • A proteomic study on human osteoblastic cells proliferation and differentiation (literal)
Abstract
  • Changes in expression profiles for 17 proteins were ascertained in human mature osteoblasts compared to pre-osteoblasts (differentiation markers). A differential approach was used to highlight proteomic changes between human osteosarcoma cells and mature osteoblasts, showing a relative over-expression of 8 proteins (proliferation and tumor indicators), as well as under-expression of proteins also found down-regulated in pre-osteoblasts (specific markers of osteoblast differentiation). Our findings confirmed the differences between cell lines and primary human cell cultures and suggested caution on the use of osteosarcoma to study anti-osteoporotic drugs in humans. (literal)
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