Cholesteryl esters in human malignant neoplasms. (Articolo in rivista)

Type
Label
  • Cholesteryl esters in human malignant neoplasms. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Tosi MR, Bottura G, Lucchi P, Reggiani A, Trinchero A, Tugnoli V (2003)
    Cholesteryl esters in human malignant neoplasms.
    in International Journal of Molecular Medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Tosi MR, Bottura G, Lucchi P, Reggiani A, Trinchero A, Tugnoli V (literal)
Pagina inizio
  • 95 (literal)
Pagina fine
  • 98 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 11 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • I.F. 2,063 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Cholesteryl esters in human malignant neoplasms. (literal)
Abstract
  • Cholesteryl esters (CholE) were detected in human malignant neoplasms by means of in vitro nuclear magnetic resonance spectroscopy. Spectroscopic analysis of the total lipid extracts obtained from cerebral tumors revealed appreciable amount of esterified cholesterol in high grade gliomas such as glioblastomas and anaplastic oligodendrogliomas, characterized by prominent neovascularity. The finding that no CholE were detected in the healthy brain and in low grade and benign tumors supports a possible correlation between this class of lipids and histological vascular proliferation. Compared with high grade gliomas, renal cell carcinomas show higher levels of CholE, absent in the healthy renal parenchyma and in benign oncocytomas. In nefro-carcinomas, cytoplasmic lipid inclusions and prominent vascularization contribute to the increased levels of CholE present mainly as oleate. CholE are discussed as potential biochemical markers of cancer and as a target for new therapeutic strategies. (literal)
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