Engagement of PI-3-kinase mediated Protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis (Articolo in rivista)

Type
Label
  • Engagement of PI-3-kinase mediated Protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cataldi A, Di Pietro R, Centurione L, Rapino M, Santavenere E, Garaci F, Cocco L, Giuliani-Piccari G, Rana R (2003)
    Engagement of PI-3-kinase mediated Protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis
    in International journal of oncology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cataldi A, Di Pietro R, Centurione L, Rapino M, Santavenere E, Garaci F, Cocco L, Giuliani-Piccari G, Rana R (literal)
Pagina inizio
  • 129 (literal)
Pagina fine
  • 135 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 22 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • I.F. 2,931 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Engagement of PI-3-kinase mediated Protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis (literal)
Abstract
  • Murine erythroleukemia cells (Friend) respond to ionizing radiation with the activation and nuclear translocation of p85alpha subunit of phosphatidylinositol-3-kinase (PI-3-kinase) which mediates the downstream activation and nuclear translocation of atypical Protein kinase C zeta (PKC zeta). This event occurs mainly upon high dose of ionizing radiation (15 Gy) and is concomitant to an increase in BrdU incorporation, which probably accounts for a predominant repair DNA synthesis. Following treatment with wortmannin, a relatively specific inhibitor of PI-3-kinase, both an increased number of apoptotic cells and the inhibition of protein kinase C zeta translocation were detected. Altogether the evidence suggests a potential role of the PI-3-kinase/PKC zeta pathway in protecting Friend cells from ionizing radiation-induced apoptosis offering PKC zeta for consideration as possible target of pharmacological treatments. (literal)
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