http://www.cnr.it/ontology/cnr/individuo/prodotto/ID5122
Engagement of PI-3-kinase mediated Protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis (Articolo in rivista)
- Type
- Label
- Engagement of PI-3-kinase mediated Protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
Cataldi A, Di Pietro R, Centurione L, Rapino M, Santavenere E, Garaci F, Cocco L, Giuliani-Piccari G, Rana R (2003)
Engagement of PI-3-kinase mediated Protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis
in International journal of oncology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Cataldi A, Di Pietro R, Centurione L, Rapino M, Santavenere E, Garaci F, Cocco L, Giuliani-Piccari G, Rana R (literal)
- Pagina inizio
- Pagina fine
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- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Engagement of PI-3-kinase mediated Protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis (literal)
- Abstract
- Murine erythroleukemia cells (Friend) respond to ionizing radiation with the activation and nuclear translocation of p85alpha subunit of phosphatidylinositol-3-kinase (PI-3-kinase) which mediates the downstream activation and nuclear translocation of atypical Protein kinase C zeta (PKC zeta). This event occurs mainly upon high dose of ionizing radiation (15 Gy) and is concomitant to an increase in BrdU incorporation, which probably accounts for a predominant repair DNA synthesis. Following treatment with wortmannin, a relatively specific inhibitor of PI-3-kinase, both an increased number of apoptotic cells and the inhibition of protein kinase C zeta translocation were detected. Altogether the evidence suggests a potential role of the PI-3-kinase/PKC zeta pathway in protecting Friend cells from ionizing radiation-induced apoptosis offering PKC zeta for consideration as possible target of pharmacological treatments.
(literal)
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