http://www.cnr.it/ontology/cnr/individuo/prodotto/ID5091
Noradrenergic and cholinergic innervation of the bone marrow (Articolo in rivista)
- Type
- Label
- Noradrenergic and cholinergic innervation of the bone marrow (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Artico M., Bosco S., Cavallotti C., Agostinelli E., Giuliani-Piccari G., Sciorino S., Cocco L., Vitale M. (2002)
Noradrenergic and cholinergic innervation of the bone marrow
in International Journal of Molecular Medicine
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Artico M., Bosco S., Cavallotti C., Agostinelli E., Giuliani-Piccari G., Sciorino S., Cocco L., Vitale M. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Noradrenergic and cholinergic innervation of the bone marrow (literal)
- Abstract
- Bone marrow is supplied by sensory and autonomic innervation. Although it
is well established that hematopoiesis is regulated by cytokines and cell-
to-cell contacts, the role played by neuromediators on the proliferation,
differentiation and release of hematopoietic cells is still controversial.
We studied the innervation of rat femur bone marrow by means of
fluorescence histochemistry and immunohistochemistry. Glyoxylic acid-
induced fluorescence was used to demonstrate catecholaminergic nerve
fibers. The immunoperoxidase method with nickel amplification was applied
to detect the distribution of nerve fibers using antibodies against the
general neuronal marker PGP 9.5 (neuron-specific cytoplasmic protein),
while the cholinacetyltransferase immunoreactivity was studied by
immunohistochemistry. Our results show the presence of an extensive
network of innervation in the rat bone marrow, providing a morphological
basis for the neural modulation of hemopoiesis. (literal)
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