http://www.cnr.it/ontology/cnr/individuo/prodotto/ID5087
Molecular characterization oh human healthy and neoplastic cerebral and renal tissues by in vitro 1H NMR spectroscopy (Articolo in rivista)
- Type
- Label
- Molecular characterization oh human healthy and neoplastic cerebral and renal tissues by in vitro 1H NMR spectroscopy (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Tosi M.R., Fini G., Tinti A., Reggiani A., Tugnoli V. (2002)
Molecular characterization oh human healthy and neoplastic cerebral and renal tissues by in vitro 1H NMR spectroscopy
in International Journal of Molecular Medicine
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Tosi M.R., Fini G., Tinti A., Reggiani A., Tugnoli V. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Molecular characterization oh human healthy and neoplastic cerebral and renal tissues by in vitro 1H NMR spectroscopy (literal)
- Abstract
- The clinical impact of (1)H NMR spectroscopy in the study of human organs,
brain and kidney in particular, is well demonstrated. The in vitro (1)H
NMR technique is a powerful tool for monitoring changes in intracellular
metabolites of human normal and neoplastic cerebral and renal tissues.
Healthy and tumoral tissues of different histologic types have been fully
characterized from a biochemical standpoint. Molecular characterization is
performed on both the aqueous and lipid extracts of surgically removed
tissue biopsies yielding a full picture of tissue biochemistry. These
analyses have disclosed markers of healthy brain and kidney and of their
respective neoplastic lesions. Moreover, some biochemical features can
differentiate neoplasms within the same histological type. In particular,
lipidic components, like cholesteryl esters (namely oleate), detected in
highest grade tumors, warrant further investigation. A better
understanding of the biochemistry of diseased human tissues could open the
way to new diagnostic and treatment strategies. (literal)
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