IL-12 and IL-15 induce activation of nuclear PLC_ in human natural killer cells (Articolo in rivista)

Type
Label
  • IL-12 and IL-15 induce activation of nuclear PLC_ in human natural killer cells (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Ponti C., Falconi M., Mariabilli A., Faenza I., Castorina S., Caimi L., Cacchioli A., Cocco L., Vitale M. (2002)
    IL-12 and IL-15 induce activation of nuclear PLC_ in human natural killer cells
    in International journal of oncology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ponti C., Falconi M., Mariabilli A., Faenza I., Castorina S., Caimi L., Cacchioli A., Cocco L., Vitale M. (literal)
Pagina inizio
  • 153 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 149 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • I.F. 2, 330 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • IL-12 and IL-15 induce activation of nuclear PLC_ in human natural killer cells (literal)
Abstract
  • Nuclear phosphoinositide breakdown mediated by nuclear PLCbeta phosphorylation is a downstream effect of IL-2 stimulation in primary human NK cells that is involved in the proliferative response to IL-2. Here we investigated whether the nuclear phosphoinositide turnover in NK cells is a response confined to IL-2, or rather represents a more general mechanism of nuclear signalling linked to the proliferative response of NK cells to activatory cytokines. We therefore focused on IL-12 and IL-15- induced nuclear events in primary human NK cells. Our results show that IL- 12 and IL-15 activate nuclear PLCbeta1 in NK cells, with delayed kinetics as compared to IL-2. The nuclear PLC activation induced by the cytokines could be blocked by the MEK-1 inhibitor PD 98059, suggesting its dependence upon MAPKinase activation. Our conclusion is that the three cytokines that activate NK cells and that bind partially similar (IL-2, IL- 15) or different surface receptors (IL-12), all induce activation of PLCbeta1 in the nucleus of NK cells via MAPKinase. Thus, the activation of nuclear PLCbeta1 appears as a physiologically relevant general mechanism of response to cytokine stimulation in human natural killer cells. (literal)

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