Direct spectroscopic evidence that the photochemical outcome of flutamide in a protein environment is tuned by modification of the molecular geometry: a comparison with the photobehavior in cyclodestrin and vesicles (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Direct spectroscopic evidence that the photochemical outcome of flutamide in a protein environment is tuned by modification of the molecular geometry: a comparison with the photobehavior in cyclodestrin and vesicles (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Sortino S., Petralia S., Condorelli G., Marconi G. (2003)
  Direct spectroscopic evidence that the photochemical outcome of flutamide in a protein environment is tuned by modification of the molecular geometry: a comparison with the photobehavior in cyclodestrin and vesicles
  in Helvetica chimica acta
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sortino S., Petralia S., Condorelli G., Marconi G. (literal)

Pagina inizio

• 266 (literal)

Pagina fine

• 273 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 86 (literal)

Rivista

• Helvetica chimica acta (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Direct spectroscopic evidence that the photochemical outcome of flutamide in a protein environment is tuned by modification of the molecular geometry: a comparison with the photobehavior in cyclodestrin and vesicles (literal)

Abstract

• The photoreactivity of the phototoxic anticancer drug flutamide (FM) in the presence of bovine serum albumin (BSA) has been investigated. The presence of BSA induces a remarkable modification of the photochemical outcome of the drug with respect to that observed in aqueous solution. Induced circular dichroism (ICD) measurements combined with theoretical calculations provide strong evidence that the new photochemical scenario is tuned by changes of the molecular geometry of FM when incorporated in the protein microenvironment. This behavior presents close analogies to that found in the presence of either cyclodestrin or phospholipid vesicles, chosen as models for biological systems, and delineates a quite general photochemical picture that can be useful for a more appropriate understanding of the adverse phototoxic effects induced by this drug. (literal)

Prodotto di

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)

Autore CNR

• GIANCARLO MARCONI (Persona)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)

Autore CNR di

• GIANCARLO MARCONI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Helvetica chimica acta (Rivista)