http://www.cnr.it/ontology/cnr/individuo/prodotto/ID50447
Core-shell nanospheres for oligonucleotide delivery. V: Adsorption/release behaviour of stealth nanospheres (Articolo in rivista)
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- Label
- Core-shell nanospheres for oligonucleotide delivery. V: Adsorption/release behaviour of stealth nanospheres (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
L. Tondelli, M. Ballestri, L. Magnani, D. Vivarelli, A. Fini, A. Cerasi, L. Chiarantini, K. Sparnacci, M. Laus (2003)
Core-shell nanospheres for oligonucleotide delivery. V: Adsorption/release behaviour of stealth nanospheres
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- L. Tondelli, M. Ballestri, L. Magnani, D. Vivarelli, A. Fini, A. Cerasi, L. Chiarantini, K. Sparnacci, M. Laus (literal)
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- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Core-shell nanospheres for oligonucleotide delivery. V: Adsorption/release behaviour of stealth nanospheres (literal)
- Abstract
- The adsorption/ release behavior of oligodeoxynucleotides (ODNs) on new PEGylated coreshell polymethylmethacrylate nanospheres is described. The outer shell consists of alkyl chains containing quaternary ammonium groups and of poly(ethylene glycol) chains, both covalently bound to the inner core. Ion pair formation between negatively charged ODN phosphate groups and positively charged groups on the nanosphere surface is the main interaction mechanism. No cellular toxicity in HL60 cells is observed at nanosphere concentrations required for biologically active ODN delivery. These results indicate that these novel cationic polymeric nanoparticles are safe and represent promising vectors for oligonucleotide delivery. (literal)
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