http://www.cnr.it/ontology/cnr/individuo/prodotto/ID50446
Immunization with HIV-1 tat DNA delivered by novel cationic block copolymers greatly enhances the CTL response against tat at very low DNA doses (Articolo in rivista)
- Type
- Label
- Immunization with HIV-1 tat DNA delivered by novel cationic block copolymers greatly enhances the CTL response against tat at very low DNA doses (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
A. Caputo, R. Gavioli, G. Altavilla, E. Brocca Cofano, C. Boarini, M. Betti, A. Castaldello, F. Lorenzini, F. Micheletti, A. Cafaro, K. Sparnacci, M. Laus, L. Tondelli, B. Ensoli (2003)
Immunization with HIV-1 tat DNA delivered by novel cationic block copolymers greatly enhances the CTL response against tat at very low DNA doses
in Vaccine
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- A. Caputo, R. Gavioli, G. Altavilla, E. Brocca Cofano, C. Boarini, M. Betti, A. Castaldello, F. Lorenzini, F. Micheletti, A. Cafaro, K. Sparnacci, M. Laus, L. Tondelli, B. Ensoli (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Immunization with HIV-1 tat DNA delivered by novel cationic block copolymers greatly enhances the CTL response against tat at very low DNA doses (literal)
- Abstract
- Cytotoxic T cell responses are key to the control of intracellular pathogens including HIV-1. In particular, HIV-1 vaccines based on
regulatory proteins, such as Tat, are aimed at controlling HIV-1 replication and at blocking disease development by inducing cytotoxic
T cell responses. Naked DNA is capable of inducing such responses but it requires several inoculations of high amounts of DNA, and/or
prime-boost regimens. Here, we showthat a novel class of cationic block copolymers protect theDNAfromDNAse I digestion, and improve
DNA delivery to antigen-presenting cells (APCs) after intramuscular (i.m.) vaccination. In particular, three cationic block copolymers (K1,
K2 and K5) were used to deliver the HIV-1 pCV-tat DNA vaccine in BALB/c mice. The results indicate that vaccination with a very
low dose (1microg) of pCV-tat delivered by the cationic block copolymer K2 is safe and, as compared to naked DNA (up to 30microg), greatly
increases the CTL response against Tat, which was detected in all animals in the absence or in the presence of re-stimulation. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Prodotto
- Autore CNR di
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi