Vibrational and thermal characterization of a new chiral drug under investigation for the therapy of congestive heart failure (Articolo in rivista)

Type
Label
  • Vibrational and thermal characterization of a new chiral drug under investigation for the therapy of congestive heart failure (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Taddei P., Torreggiani A., Fini G. (2002)
    Vibrational and thermal characterization of a new chiral drug under investigation for the therapy of congestive heart failure
    in Journal of molecular structure (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Taddei P., Torreggiani A., Fini G. (literal)
Pagina inizio
  • 63 (literal)
Pagina fine
  • 70 (literal)
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  • 642 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Biochimica \"G. Moruzzi\", Sezione di Chimica e Propedeutica Biochimica, University of Bologna, Via Belmeloro 8/2, (literal)
Titolo
  • Vibrational and thermal characterization of a new chiral drug under investigation for the therapy of congestive heart failure (literal)
Abstract
  • Racemic (5,6-bis 2-methyl propanoic acid-1,2,3,4-tetrahydro-naphtalen-2-yl)-methylammonium chloride, CHF-1035, under clinical investigation for the treatment of congestive heart failure, was here characterised by Raman and IR spectroscopies coupled with thermal analysis (thermogravimetry and differential scanning calorimetry). These techniques proved suitable for investigating the presence of different polymorphic forms, their relative stability and interconversion tendency in relation to industrial manufacturing processes undergone by the drug (i.e. grinding, compression, heating). Crystallisation experiments were carried out and two different CHF-1035 polymorphic forms were identified. Both grinding and heating revealed to cause a polymorphic transformation of the drug crystal form. It was hypothesised that a change in molecular packing occurs in the drug by effect of both treatments. The possible sources of polymorphism were identified in the -OCyOCH(CH3) groups and in the saturated ring. The non-ground sample showed two endothermic transitions; since they are reversible and not due to desolvation processes the system is probably enantiotropic. (literal)
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