http://www.cnr.it/ontology/cnr/individuo/prodotto/ID50262

CASP-9 : a susceptibility locus for multiple sclerosis in Italy. (Articolo in rivista)

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CASP-9 : a susceptibility locus for multiple sclerosis in Italy. (Articolo in rivista) (literal)

Anno

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Alternative label

Andreoli V, Trecroci F, La Russa A., Valentino P., Condino F., Latorre V., Nisticò R., Pirritano D, Del Giudice F., Canino M., Cittadella R. and Quattrone A. (2009)
CASP-9 : a susceptibility locus for multiple sclerosis in Italy.
in Journal of neuroimmunology (Print)
(literal)

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Andreoli V, Trecroci F, La Russa A., Valentino P., Condino F., Latorre V., Nisticò R., Pirritano D, Del Giudice F., Canino M., Cittadella R. and Quattrone A. (literal)

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Rivista

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Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza; Institute of Neurology, University Magna Graecia, Catanzaro, Italy. (literal)

Titolo

Abstract

Caspase-9 is a primary effector CASP that executes programmed cell death, which plays an important role in the development of multiple sclerosis (MS). Polymorphisms in the CASP-9 gene may influence its activity, thereby modulating the susceptibility to MS. To test this hypothesis, we evaluated a SNP in the CASP-9 gene in a set of Italian patients from Southern Italy and healthy control subjects. Our results suggest that the presence of the G/G genotype represents a higher risk factor in our MS population and a differential production of CASP-9 might be a contributory factor in determining the severity of MS. (literal)

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