TLQP-21, a VGF-Derived Peptide, Prevents Ethanol-Induced Gastric Lesions: Insights into Its Mode of Action (Articolo in rivista)

Type
Label
  • TLQP-21, a VGF-Derived Peptide, Prevents Ethanol-Induced Gastric Lesions: Insights into Its Mode of Action (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1159/000319791 (literal)
Alternative label
  • Sibilia V. 1); Pagani F. 1); Bulgarelli I. 1); Mrak E. 1); Broccardo M. 2); Improta G. 2); Severini C. 3); Possenti R. 3),4); Guidobono F. 1) (2010)
    TLQP-21, a VGF-Derived Peptide, Prevents Ethanol-Induced Gastric Lesions: Insights into Its Mode of Action
    in Neuroendocrinology (Basel)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sibilia V. 1); Pagani F. 1); Bulgarelli I. 1); Mrak E. 1); Broccardo M. 2); Improta G. 2); Severini C. 3); Possenti R. 3),4); Guidobono F. 1) (literal)
Pagina inizio
  • 189 (literal)
Pagina fine
  • 197 (literal)
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  • 2010 Aug 30. [Epub ahead of print] - Published online: 4 December 2010 (literal)
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  • 92 (literal)
Rivista
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  • 3 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1) Department of Pharmacology, Chemotherapy and Medical Toxicology, Università degli Studi di Milano, Milano, Italy; 2) Department of Human Physiology and Pharmacology ‘V. Erspamer’, University ‘La Sapienza’, Rome, Italy; 3) Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy; 4) Department of Neuroscience, University ‘Tor Vergata’, Rome, Italy. (literal)
Titolo
  • TLQP-21, a VGF-Derived Peptide, Prevents Ethanol-Induced Gastric Lesions: Insights into Its Mode of Action (literal)
Abstract
  • Background and Aim: TLQP-21, a peptide derived from the vgf gene, has been reported to play a role in the regulation of rat gastric motility, but its influence on gastric mucosal integrity is unknown. Experimental Approach: We investigated the effects of central (0.8-8 nmol/rat) or peripheral (48-240 nmol/kg) TLQP-21 administration on ethanol- (EtOH, 50%, 1 ml/rat) induced gastric lesions in the rat. The mechanisms involved in such activity were also examined. Results: Central TLQP-21 injection dose-dependently reduced EtOH-induced gastric lesions (ED(50) = 3.16 nmol), while peripheral TLQP-21 administration had no effect. The TLQP-21 gastroprotective effect against EtOH injury was accompanied by a significant increase in gastric prostaglandin E(2) (PGE(2)) production linked to an increase in constitutive cyclooxygenase (COX) expression. The nitric oxide (NO) synthase inhibitor L-NAME (70 mg/kg, s.c.), the nonselective COX inhibitor indomethacin (10 mg/kg, orally) and capsaicin denervation removed TLQP-21 gastroprotection. Conclusions: This study shows for the first time that central TLQP-21 exerts a protective action on the gastric mucosa exposed to the noxious agent EtOH. TLQP-21 gastroprotection is mediated by constitutive-derived NO and PGE(2), and requires the integrity of sensory nerve fibers. (literal)
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