Nerve growth factor in the developing and adult lacrimal glands of rat with and without inherited retinitis pigmentosa (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Nerve growth factor in the developing and adult lacrimal glands of rat with and without inherited retinitis pigmentosa (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Muzi S., Colafrancesco V., Sornelli F., Mantelli F., Lambiase A., Aloe L. (2010)
  Nerve growth factor in the developing and adult lacrimal glands of rat with and without inherited retinitis pigmentosa
  in Cornea
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Muzi S., Colafrancesco V., Sornelli F., Mantelli F., Lambiase A., Aloe L. (literal)

Pagina inizio

• 1163 (literal)

Pagina fine

• 1168 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• doi: 10.1097/ICO.0b013e3181d3d3f9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 29/10 (literal)

Rivista

• Cornea (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Nerve growth factor in the developing and adult lacrimal glands of rat with and without inherited retinitis pigmentosa (literal)

Abstract

• Purpose: In the present study, we investigated lacrimal function and presence of the neurotrophin nerve growth factor (NGF) and its receptors in the lacrimal gland (LG) of normal rats and rats with inherited retinitis pigmentosa (IRP). Materials and Methods: After anesthesia, modified Schirmer tests were performed on IRP rats and Sprague Dawley (SD) rats to measure tear function. LGs of developing and adult IRP and SD rats were removed and used for histological, immunohistochemical, and biochemical analyses. Results: The results showed that basal tear secretion is reduced in IRP rats as compared with SD rats. NGF and NGF receptors are expressed in the LG of both rat strains. In SD rats, these NGF markers are low during early life and more elevated in adult life. Conversely in rats with IRP, NGF and its receptors decreased in adult life. Conclusions: The role of NGF in maintaining ocular surface integrity is well known. The observations of this study further support the hypothesis that neurotrophins play a role in modulating tear secretion and probably in preventing the deleterious effects of dry eye. This hypothesis is presented and discussed. (literal)

Prodotto di

• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• LUIGI ALOE (Unità di personale interno)
• FEDERICA SORNELLI (Unità di personale esterno)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)

Autore CNR di

• LUIGI ALOE (Unità di personale interno)
• FEDERICA SORNELLI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cornea (Rivista)