Genes and pathways differentially expressed in the brains of Fxr2 knockout mice (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Genes and pathways differentially expressed in the brains of Fxr2 knockout mice (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.nbd.2008.09.008 (literal)

Alternative label

• Cavallaro S, Paratore S, Fradale F, de Vrij FM, Willemsen R, Oostra BA. (2008)
  Genes and pathways differentially expressed in the brains of Fxr2 knockout mice
  in Neurobiology of disease
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cavallaro S, Paratore S, Fradale F, de Vrij FM, Willemsen R, Oostra BA. (literal)

Pagina inizio

• 510 (literal)

Pagina fine

• 520 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 32 (literal)

Rivista

• Neurobiology of disease (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Functional Genomics Center, Institute of Neurological Sciences, Italian National Research Council, Catania, Italy b Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands (literal)

Titolo

• Genes and pathways differentially expressed in the brains of Fxr2 knockout mice (literal)

Abstract

• Fragile X syndrome is a common inherited form of mental retardation and originates from the absence of expression of the FMR1 gene. This gene and its two homologues, FXR1 and FXR2, encode for a family of fragile X related (FXR) proteins with similar tissue distribution, together with sequence and functional homology. Based on these characteristics, it has been suggested that these proteins might partly complement one another. To unravel the function of Fxr2 protein, the expression pattern of 12,588 genes was studied in the brains of wild-type and Fxr2 knockout mice, an animal model which shows behavioral abnormalities partly similar to those observed in Fmr1-knockout mice. By genome expression profiling and stringent significance tests we identify genes and gene groups de-regulated in the brains of Fxr2 knockout mice. Differential expression of candidate genes was validated by real-time PCR, in situ hybridization, immunohistochemistry and western blot analysis. A number of differentially expressed genes associated with the Fxr2 phenotype have been previously involved in other memory or cognitive disorders. (literal)

Prodotto di

• Genomica funzionale delle malattie ereditarie del sistema nervoso (ME.P05.010.001) (Modulo)
• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• SEBASTIANO CAVALLARO (Unità di personale interno)
• FRANCESCO FRADALE (Persona)
• SABRINA PARATORE (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Genes and pathways differentially expressed in the brains of Fxr2 knockout mice" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• SEBASTIANO CAVALLARO (Unità di personale interno)
• SABRINA PARATORE (Unità di personale esterno)
• FRANCESCO FRADALE (Persona)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Genomica funzionale delle malattie ereditarie del sistema nervoso (ME.P05.010.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurobiology of disease (Rivista)

Insieme di parole chiave di

• Keywords of "Genes and pathways differentially expressed in the brains of Fxr2 knockout mice" (Insieme di parole chiave)