Myocardial 123metaiodobenzylguanidine uptake in genetic Parkinson's disease. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Myocardial 123metaiodobenzylguanidine uptake in genetic Parkinson's disease. (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/mds.21701 (literal)

Alternative label

• Quattrone A; Bagnato A; Annesi G; Novellino F; Morgante L; Savettieri G; Zappia M; Tarantino P; Candiano IC; Annesi F; Civitelli D; Rocca FE; D'Amelio M; Nicoletti G; Morelli M; Petrone A; Loizzo P; Condino F. (2008)
  Myocardial 123metaiodobenzylguanidine uptake in genetic Parkinson's disease.
  in Movement disorders
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Quattrone A; Bagnato A; Annesi G; Novellino F; Morgante L; Savettieri G; Zappia M; Tarantino P; Candiano IC; Annesi F; Civitelli D; Rocca FE; D'Amelio M; Nicoletti G; Morelli M; Petrone A; Loizzo P; Condino F. (literal)

Pagina inizio

• 21 (literal)

Pagina fine

• 27 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Movement disorders (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Quattrone A: Institute of Neurology, University Magna Graecia, Catanzaro, Italy-Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy Bagnato A: Department of Nuclear Medicine, Azienda Ospedaliera, Cosenza, Italy Annesi G: Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy Novellino F: Institute of Neurology, University Magna Graecia, Catanzaro, Italy-Institute of Neurological Morgante L: Department of Neuroscience, Psychiatry and Anesthesiology, University of Messina, Messina, Italy Savettieri G: Department of Clinical Neurosciences, University of Palermo, Palermo, Italy Zappia M: Department of Neurosciences, University of Catania, Catania, Italy Tarantino P: Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy Candiano IC: Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy Annesi F: Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy Civitelli D: Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy Rocca FE: Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy D'Amelio M: Department of Clinical Neurosciences, University of Palermo, Palermo, Italy Nicoletti G: Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy Morelli M: Institute of Neurology, University Magna Graecia, Catanzaro, Italy-Institute of Neurological Petrone A: Department of Neurosciences, Azienda Ospedaliera, Cosenza, Italy Loizzo P: Department of Nuclear Medicine, Azienda Ospedaliera, Cosenza, Italy Condino F: Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy (literal)

Titolo

• Myocardial 123metaiodobenzylguanidine uptake in genetic Parkinson's disease. (literal)

Abstract

• Abstract: Myocardial 123Metaiodobenzylguanidine (MIBG) enables the assessment of postganglionic sympathetic cardiac innervation. MIBG uptake is decreased in nearly all patients with Parkinson's disease (PD). Our objective was to evaluate MIBG uptake in patients with genetic PD. We investigated MIBG uptake in 14 patients with PD associated with mutations in different genes (Parkin, DJ-1, PINK1, and leucine-rich repeat kinase 2 -LRRK2), in 15 patients with idiopathic PD, and 10 control subjects. The myocardial MIGB uptake was preserved in 3 of the 4 Parkin-associated Parkinsonisms, in 1 of the 2 patients with DJ-1 mutations, in 1 of the 2 brothers with PINK1 mutations, in 3 of the 6 unrelated patients with Gly2019Ser mutation in the LRRK2 gene, whereas it was impaired in all patients with idiopathic PD. MIBG was preserved in all control subjects. Our study shows that myocardial MIGB uptake was normal in 8 of 14 patients with genetic PD, suggesting that cardiac sympathetic denervation occurs less frequently in genetic PD than in idiopathic PD. Our findings also demonstrate that MIGB uptake has a heterogeneous pattern in genetic PD, because it was differently impaired in patients with different mutations in the same gene or with the same gene mutation. (literal)

Prodotto di

• Genetica delle malattie multifattoriali (ME.P02.012.002) (Modulo)
• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• GIUSEPPE NICOLETTI (Persona)
• GRAZIA ANNESI (Unità di personale interno)
• FABIANA NOVELLINO (Persona)
• INNOCENZA CIRO' CANDIANO (Persona)
• FERDINANDA ANNESI (Unità di personale interno)
• FRANCESCA EMANUELA ROCCA (Unità di personale esterno)
• PATRIZIA TARANTINO (Persona)
• DONATELLA CIVITELLI (Unità di personale interno)

Incoming links:

Autore CNR di

• GIUSEPPE NICOLETTI (Persona)
• FERDINANDA ANNESI (Unità di personale interno)
• GRAZIA ANNESI (Unità di personale interno)
• DONATELLA CIVITELLI (Unità di personale interno)
• FRANCESCA EMANUELA ROCCA (Unità di personale esterno)
• INNOCENZA CIRO' CANDIANO (Persona)
• PATRIZIA TARANTINO (Persona)
• FABIANA NOVELLINO (Persona)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Genetica delle malattie multifattoriali (ME.P02.012.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Movement disorders (Rivista)