Primary afferent plasticity following deafferentation of the trigeminal brainstem nuclei in the adult rat (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Primary afferent plasticity following deafferentation of the trigeminal brainstem nuclei in the adult rat (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• De Riu PL, Russo A., Pellitteri R, Stanzani S, Tringali G, Roccazzello AM, De Riu G, Marongiu P, Mameli O (2008)
  Primary afferent plasticity following deafferentation of the trigeminal brainstem nuclei in the adult rat
  in Experimental neurology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• De Riu PL, Russo A., Pellitteri R, Stanzani S, Tringali G, Roccazzello AM, De Riu G, Marongiu P, Mameli O (literal)

Pagina inizio

• 101 (literal)

Pagina fine

• 107 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 213 (literal)

Rivista

• Experimental neurology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• aDepartment of Biomedical Science, Human Physiology Division, University of Sassari, Sassari 07100, Italy bDepartment of Physiological Sciences, University of Catania, Catania, Italy cInstitute of Neurological Science, National Research Council, Catania Section, Catania, Italy dI.R.M.A., Acireale, Catania, Italy (literal)

Titolo

• Primary afferent plasticity following deafferentation of the trigeminal brainstem nuclei in the adult rat (literal)

Abstract

• Alpha-tyrosinated tubulin is a cytoskeletal protein that is involved in axonal growth and is considered a marker of neuronal plasticity in adult mammals. In adult rats, unilateral ablation of the left facial sensorimotor cortical areas induces degeneration of corticotrigeminal projections and marked denervation of the contralateral sensory trigeminal nuclei. Western blotting and real-time-PCR of homogenates of the contralateral trigeminal ganglion (TG) revealed consistent overexpression of growth proteins 15 days after left decortication in comparison with the ipsilateral side. Immunohistochemical analyses indicated marked overexpression of alpha-tyrosinated tubulin in the cells of the ganglion on the right side. Cytoskeletal changes were primarily observed in the small ganglionic neurons. Application of HRP-CT, WGA-HRP, and HRP to infraorbital nerves on both sides 15 days after left decortication showed a significant degree of terminal sprouting and neosynaptogenesis from right primary afferents at the level of the right caudalis and interpolaris trigeminal subnuclei. These observations suggest that the adaptive response of TG neurons to central deafferentation, leading to overcrowding and rearrangement of the trigeminal primary afferent terminals on V spinal subnuclei neurons, could represent the anatomical basis for distortion of facial modalities, perceived as allodynia and hyperalgesia, despite nerve integrity. (literal)

Prodotto di

• Institute of neurological sciences (ISN) (Istituto)
• Markers molecolari nelle malattie ereditarie e tumori del Sistema Nervoso (ME.P02.011.001) (Modulo)

Autore CNR

• ROSALIA MARIA CRISTINA PELLITTERI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Primary afferent plasticity following deafferentation of the trigeminal brainstem nuclei in the adult rat" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ROSALIA MARIA CRISTINA PELLITTERI (Unità di personale interno)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Markers molecolari nelle malattie ereditarie e tumori del Sistema Nervoso (ME.P02.011.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Experimental neurology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Primary afferent plasticity following deafferentation of the trigeminal brainstem nuclei in the adult rat" (Insieme di parole chiave)