Genetically-dependent modulation of serotonergic inactivation in the human prefrontal cortex. (Articolo in rivista)

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  • Genetically-dependent modulation of serotonergic inactivation in the human prefrontal cortex. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.neuroimage.2007.12.028 (literal)
Alternative label
  • Passamonti L; Cerasa A; Gioia MC; Magariello A; Muglia M; Quattrone A; Fera F (2008)
    Genetically-dependent modulation of serotonergic inactivation in the human prefrontal cortex.
    in NeuroImage (Orlando Fla., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Passamonti L; Cerasa A; Gioia MC; Magariello A; Muglia M; Quattrone A; Fera F (literal)
Pagina inizio
  • 1264 (literal)
Pagina fine
  • 1273 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S1053811907011421 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 40 (literal)
Rivista
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  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Medical Research Council, Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, UK b National Research Council, Institute of Neurological Sciences, Piano Lago di Mangone (CS), 87050, Italy c Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 2QQ, UK d Medical Research Council Behavioural and Clinical Neurosciences Institute, Downing Site, Cambridge, CB2 3E, UK (literal)
Titolo
  • Genetically-dependent modulation of serotonergic inactivation in the human prefrontal cortex. (literal)
Abstract
  • Previous research suggests that genetic variations regulating serotonergic neurotransmission mediate individual differences in the neural network underlying impulsive and aggressive behaviour. Although with conflicting findings, the monoamine oxidase-A (MAOA) and the serotonin transporter (5HTT) gene polymorphisms have been associated with an increased risk to develop impulsive and aggressive behaviour. Double knock-out mice studies have also demonstrated that MAOA and 5HTT genes strongly interact in the metabolic pathway leading to the serotonergic inactivation; however, their potential interactive effect in human brain remains uninvestigated. We used blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to assess the independent and interactive effects of both MAOA and 5HTT polymorphisms on the brain activity elicited by a response inhibition task in healthy volunteers. Multivariate analysis demonstrated an individual effect of both MAOA and 5HTT polymorphisms and a strong allele-allele interaction in the anterior cingulate cortex (ACC), a key region implicated in cognitive control and in the pathophysiology of impulsive and aggressive behaviour. These findings suggest that the MAOAx5HTT allelic interaction exerts a significant modulation on the BOLD response associated with response inhibition and contribute to validate haplotype models as useful tools for a better understanding of the neurobiology underlying complex cognitive functions. (literal)
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