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Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes. (Articolo in rivista)
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- Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.expneurol.2006.08.007 (literal)
- Alternative label
Musumeci SA, Calabrese G, Bonaccorso CM, D'Antoni S, Brouwer JR, Bakker CE, Elia M, Ferri R, Nelson DL, Oostra BA, Catania MV. (2007)
Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes.
in Experimental neurology; Academic Press Elsevier, Inc., San Diego (Stati Uniti d'America)
(literal)
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- Musumeci SA, Calabrese G, Bonaccorso CM, D'Antoni S, Brouwer JR, Bakker CE, Elia M, Ferri R, Nelson DL, Oostra BA, Catania MV. (literal)
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- ISI Web of Science (WOS) (literal)
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- Oasi Maria SS- Troina (It), ISN- CNR, Erasmus University Rotterdam, University of Texas (literal)
- Titolo
- Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes. (literal)
- Abstract
- The Fmr1 knockout (KO) mouse is characterized by an increased audiogenic seizure
(AGS) susceptibility and is considered a good animal model for epilepsy and
seizures in the human fragile-X (FRAX) syndrome. Here, we tested the hypothesis
that the reintroduction of the FMR1 gene is able to revert the AGS susceptibility
characterizing Fmr1 KO mice. To this aim, two groups of Fmr1 KO transgenic mice,
which have additional copies of the human FMR1 gene (YAC) or FMR1 cDNA (G6) were
used. AGS susceptibility of these mice was examined and compared to that of Fmr1
KO, wild type, and wild-type animals in whom the FMR1gene was also introduced
(over-expressed). Mice were tested at different ages because AGS susceptibility
is age dependent. The intensity of response was scored and the results were
analyzed by means of 2-way analysis of variance to evaluate the effects of age
and genetic condition. We found that AGS susceptibility rescue is complete in the
G6 mice and partial in YAC mice. Our data indicate that the introduction of the
human FMR1 gene in Fmr1 KO mice is able to revert the Fmr1 KO epileptic
phenotype. (literal)
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