The role of VLA4 polymorphisms in Multiple Sclerosis: an association study. (Articolo in rivista)

Type
Label
  • The role of VLA4 polymorphisms in Multiple Sclerosis: an association study. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.jneuroim.2007.06.015 (literal)
Alternative label
  • V. Andreoli, R. Cittadella, P. Valentino, F. Condino, A. La Russa, M. Liguori, I. Manna, P. Spadafora, R. Nisticò, D. Pirritano, A. Clodomiro, and A. Quattrone. (2007)
    The role of VLA4 polymorphisms in Multiple Sclerosis: an association study.
    in Journal of neuroimmunology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • V. Andreoli, R. Cittadella, P. Valentino, F. Condino, A. La Russa, M. Liguori, I. Manna, P. Spadafora, R. Nisticò, D. Pirritano, A. Clodomiro, and A. Quattrone. (literal)
Pagina inizio
  • 125 (literal)
Pagina fine
  • 128 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 189 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza; Institute of Neurology, Campus di Germaneto, University Magna Graecia, Catanzaro, Italy. (literal)
Titolo
  • The role of VLA4 polymorphisms in Multiple Sclerosis: an association study. (literal)
Abstract
  • Lymphocyte and monocyte brain infiltration determines inflammation in multiple sclerosis. The trafficking of these cells into the CNS results from the VLA-4 binding with its ligand on brain endothelial cells. MS patients treated with an antibody against the alpha-4 subunit, which inhibits this interaction, prevents brain lesion development. We investigated the association between VLA-4 gene polymorphisms and MS in a study on 275 patients and 255 controls. No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy. (literal)
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