Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction (Articolo in rivista)

Type
Label
  • Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Sonvico, F; Cagnani, A; Rossi, A; Motta, S; Di Bari, MT; Cavatorta, F; Alonso, MJ; Deriu, A; Colombo, P (2006)
    Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction
    in International journal of pharmaceutics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sonvico, F; Cagnani, A; Rossi, A; Motta, S; Di Bari, MT; Cavatorta, F; Alonso, MJ; Deriu, A; Colombo, P (literal)
Pagina inizio
  • 67 (literal)
Pagina fine
  • 73 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 324 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ Parma, Dipartimento Farmaceut, I-43100 Parma, Italy; Natl Inst Phys Matter, INFM, Res Unit Parma, Parma, Italy; Univ Santiago de Compostela, Dept Pharmaceut Technol, Santiago De Compostela, Spain; Univ Milan, Dipartimento Chim Biochim & Biotecnol Med, I-20122 Milan, Italy (literal)
Titolo
  • Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction (literal)
Abstract
  • In this work the production of auto-assembled nanoparticles obtained by the mixing of chitosan and lecithin is presented. The size and surface charge of the nanoparticles were studied as function of the weight ratio between components, the viscosity of the polysaccharide and the pH of the colloidal suspension. In order to elucidate the structure of nanoparticles, micro-FT-IR and elastic neutron scattering experiments have been performed. Results evidenced a strong electrostatic interaction between components and a structure that is neither that of homogeneous spheres nor of coated unilamellar vesicles. Preliminary encapsulation experiments with progesterone, as model lipophilic drug, showed good encapsulation efficiencies. (c) 2006 Elsevier B.V. All rights reserved. (literal)
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