http://www.cnr.it/ontology/cnr/individuo/prodotto/ID49982
Treatment of multiple sclerosis with interferon beta in clinical practice: 2-year follow-up data from the South Italy Mobile MRI Project. (Articolo in rivista)
- Type
- Label
- Treatment of multiple sclerosis with interferon beta in clinical practice: 2-year follow-up data from the South Italy Mobile MRI Project. (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Alternative label
Bonavita S, Dinacci D, Lavorgna L, Savettieri G, Quattrone A, Livrea P, Bresciamorra V, Orefice G, Paciello M, Coniglio G, Di Costanzo A, Valentino P, Patti F, Salemi G, Simone I, Tedeschi G. (2006)
Treatment of multiple sclerosis with interferon beta in clinical practice: 2-year follow-up data from the South Italy Mobile MRI Project.
in Neurological sciences (Testo stamp.)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bonavita S, Dinacci D, Lavorgna L, Savettieri G, Quattrone A, Livrea P, Bresciamorra V, Orefice G, Paciello M, Coniglio G, Di Costanzo A, Valentino P, Patti F, Salemi G, Simone I, Tedeschi G. (literal)
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- ISI Web of Science (WOS) (literal)
- Titolo
- Treatment of multiple sclerosis with interferon beta in clinical practice: 2-year follow-up data from the South Italy Mobile MRI Project. (literal)
- Abstract
- This follow-up study assessed the 2-year clinical
and magnetic resonance imaging (MRI) outcomes of
patients with multiple sclerosis (MS) originally enrolled in
an MRI study conducted at eight centres in south Italy (the
South Italy Mobile MRI Project). Of the 597 MS patients
recruited at baseline, 391 returned for the follow-up study.
Of these, 363 provided 2-year clinical and MRI follow-up
data, and 215 were still undergoing treatment with one of
four interferon beta regimens: Avonex, 30 mcg intramuscularly
once weekly; Betaferon, 250 mcg subcutaneously
(sc) every other day; Rebif 22 mcg sc three times weekly
(tiw; Rebif 22); or Rebif 44 mcg sc tiw (Rebif 44). Over
the 2-year follow-up period, patients receiving the higher
dose of Rebif were more likely to remain free from relapses
[odds ratio (OR) = 2.23] and from developing both new
T2 (OR = 0.15) and new T1 black hole lesions (OR =
0.22), when compared with patients in the Avonex group.
Despite some limitations in the trial design, the results
from this follow-up study provide helpful clinical and MRI
data on the efficacy of interferon beta regimens in MS
patients treated in the clinical setting. (literal)
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