Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity (Articolo in rivista)

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  • Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.biopsych.2005.07.027 (literal)
Alternative label
  • Passamonti L; Fera F; Magariello A; Cerasa A; Gioia MC; Muglia M; Nicoletti G; Gallo O; Provinciali L; Quattrone A (2006)
    Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity
    in Biological psychiatry (1969)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Passamonti L; Fera F; Magariello A; Cerasa A; Gioia MC; Muglia M; Nicoletti G; Gallo O; Provinciali L; Quattrone A (literal)
Pagina inizio
  • 334 (literal)
Pagina fine
  • 340 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0006322305009169 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 59 (literal)
Rivista
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  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 59 (literal)
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  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • From the Neurology Unit, Department of Neurosciences, University \"Politecnica delle Marche,\" Ancona (Passamonti, Provinciali); Institute of Neurological Sciences, National Research Council, Piano Lago di Magone, Cosenza (Fera, Magariello, Cerasa, Gioia, Muglia, Nicoletti, Gallo, Quattrone); and Institute of Neurology, University \"Magna Graecia,\" Catanzaro, Italy (Quattrone). (literal)
Titolo
  • Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity (literal)
Abstract
  • BACKGROUND: Previous evidence has shown that genetic variations in the serotonergic system contribute to individual differences in personality traits germane to impulse control. The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. High-activity allele carriers have higher enzyme expression, lower amine concentration, and present higher scores on behavioral measures of impulsivity than low-activity allele carriers. METHODS: We studied the relationship of this polymorphism to brain activity elicited by a response inhibition task (Go/NoGo task), using blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging in 24 healthy men. RESULTS: Direct comparison between groups revealed a greater BOLD response in the right ventrolateral prefrontal cortex (Brodmann's area [BA] 45/47) in high-activity allele carriers, whereas a greater response in the right superior parietal cortex (BA 7) and bilateral extrastriate cortex (BA 18) was found in low-activity allele carriers. CONCLUSIONS: These data suggest that a specific genetic variation involving serotonergic catabolism can modulate BOLD response associated with human impulsivity. (literal)
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