Association of the 5-HT6 receptor gene polymorphism C267T with Parkinson's disease. (Articolo in rivista)

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  • Association of the 5-HT6 receptor gene polymorphism C267T with Parkinson's disease. (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Messina D,1; Annesi G,1, Serra P,1, Nicoletti G,1, Pasqua A,1, Annesi F,1, Tomaino C,1, Cirò Candiano IC,1, Carrideo S,1, Caracciolo M,1, Spadafora P,1, Zappia M,2, Savettieri G,3, Quattrone A.1-2 (2002)
    Association of the 5-HT6 receptor gene polymorphism C267T with Parkinson's disease.
    in Neurology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Messina D,1; Annesi G,1, Serra P,1, Nicoletti G,1, Pasqua A,1, Annesi F,1, Tomaino C,1, Cirò Candiano IC,1, Carrideo S,1, Caracciolo M,1, Spadafora P,1, Zappia M,2, Savettieri G,3, Quattrone A.1-2 (literal)
Pagina inizio
  • 828 (literal)
Pagina fine
  • 829 (literal)
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  • 58 (literal)
Rivista
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  • In this study, we investigated whether the allelic variant C267T of the 5-HT6 gene could contribute to the risk for developing PD. We found that individuals carrying the T allele had a significantly lower risk for developing PD. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1,Institute of Experimental Medicine and Biotechnology, National Research Council, Piano Lago di Mangone - Cosenza (ora ISN), 2,Institute of Neurology, School of Medicine Catanzaro 3, Institute of Neuropsychiatry, University of Palermo, Palermo, Italy. (literal)
Titolo
  • Association of the 5-HT6 receptor gene polymorphism C267T with Parkinson's disease. (literal)
Abstract
  • The effects of serotonin (5-HT) in the CNS are mediated through receptor subtypes distinguished by seven major families. The 5-HT6 receptor gene maps to the human chromosome region 1p35-p36 and a polymorphism (C267T) of the 5-HT6 gene has been associated with the risk of developing schizophrenia.Unlike most 5-HT receptors, the 5-HT6 receptor is highly expressed in the striatum,suggesting a possible involvement of this receptor in the extrapyramidal function. In this study, we investigated whether the allelic variant C267T of the 5-HT6 gene could contribute to the risk for developing PD. (literal)
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