Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance. (Articolo in rivista)

Type
Label
  • Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance. (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Alternative label
  • Tishkoff SA, Varkonyi R, Cahinhinan N, Abbes S, Argyropoulos G, Destro-Bisol G, Drousiotou A, Dangerfield B, Lefranc G, Loiselet J, Piro A, Stoneking M, Tagarelli A, Tagarelli G, Touma EH, Williams SM, Clark AG (2001)
    Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance.
    in Science (New York, N.Y.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Tishkoff SA, Varkonyi R, Cahinhinan N, Abbes S, Argyropoulos G, Destro-Bisol G, Drousiotou A, Dangerfield B, Lefranc G, Loiselet J, Piro A, Stoneking M, Tagarelli A, Tagarelli G, Touma EH, Williams SM, Clark AG (literal)
Pagina inizio
  • 455 (literal)
Pagina fine
  • 462 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 293 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5529 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • The origins of malaria resistance in humans, the evolutionary history of the G6PD locus, and the age estimates of the A- and Med alleles are described. Haplotypes analysis of A- and Med mutations at G6PD locus indicates that they have evolved independently and have increased in frequency at a rate that is too rapid to be explained by random genetic drift (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ.of Maryland,USA;Pennsylvania State Univ.,USA;Fac. of Med. & Pasteur Inst., Tunis,Tunisia;Louisiana State Univ.,USA;Univ.La Sapienza, Rome,Italy;The Cyprus Inst.of Neurol. and Gen., Nicosia, Cyprus;Univ. of the Witwaterserand, Johannesburg, South Africa;Univ. of Sc. and CNRS, Montpellier, France;Univ. St. Joseph, Beirut, Lebonan;Inst. of Exp. Med. and Biotecn.-CNR, Cosenza,Italy;Max Planck Inst. Leipzig, Germany;Meharry Med. College, Nashville, USA (literal)
Titolo
  • Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance. (literal)
Abstract
  • The frequencies of low-activity alleles of glucose-6-phosphate dehydrogenase in humans are highly correlated with the prevalence of malaria. These \"deficiency\" alleles are thought to provide reduced risk from infection by the Plasmodium parasite and are maintained at high frequency despite the hemopathologies that they cause. Haplotype analysis of \"A-\" and \"Med\" mutations at this locus indicates that they have evolved independently and have increased in frequency at a rate that is too rapid to be explained by random genetic drift. Statistical modeling indicates that the A- allele arose within the past 3840 to 11,760 years and the Med allele arose within the past 1600 to 6640 years. These results support the hypothesis that malaria has had a major impact on humans only since the introduction of agriculture within the past 10,000 years and provide a striking example of the signature of selection on the human genome. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it