CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Gomez-Lira M,1; Liguori M,2; Magnani C,3; Bonamini D,1; Salviati A,4; Leone M,5; Andreoli V,2; Trojano M,6; Valentino P,7; Savettieri G,8 Quattrone A,2-7; Pignatti PF,1; Momigliano-Richiardi P,9; Giordano M.9 (2003)
  CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers.
  in Journal of neuroimmunology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gomez-Lira M,1; Liguori M,2; Magnani C,3; Bonamini D,1; Salviati A,4; Leone M,5; Andreoli V,2; Trojano M,6; Valentino P,7; Savettieri G,8 Quattrone A,2-7; Pignatti PF,1; Momigliano-Richiardi P,9; Giordano M.9 (literal)

Pagina inizio

• 216 (literal)

Pagina fine

• 221 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 140 (literal)

Rivista

• Journal of neuroimmunology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers. (literal)

Abstract

• We re-evaluated the association with multiple sclerosis (MS) of the C77G splicing regulatory variation in the CD45 gene and screened for new mutations the three alternatively spliced exons (#4, 5 and 6). No association with C77G was detected in two groups of patients (total=448) and controls (total=559) from Northern and Southern Italy. When excluding the first published study indicating a positive association, a meta-analysis of the five further studies conducted to date (including the present one) led to a non-significant combined odds ratio (OR) of 1.11. None of the four newly identified nucleotide substitutions, namely C77T (Pro59Pro) in exon 4, G69C (Asp121His) in exon 5, T127A (Ile187Asn) and A138G (Thr191Ala) in exon 6, was significantly associated to MS. (literal)

Prodotto di

• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• VIRGINIA ANDREOLI (Persona)
• MARIA LIGUORI (Persona)

Incoming links:

Autore CNR di

• VIRGINIA ANDREOLI (Persona)
• MARIA LIGUORI (Persona)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neuroimmunology (Rivista)