Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155 (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155 (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• (1) Levati L, (2) Alvino E, (1) Pagani E, (1) ArcelliD, (1) Caporaso P, (3) Bondanza S, (4, 5) Di Leva G, (6,7) Ferracin M, (4, 5, 8) Volinia S, (2, 9) Bonmassar E, (4, 5) Croce CM, (1) D'Atri S. (2009)
  Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155
  in International journal of oncology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• (1) Levati L, (2) Alvino E, (1) Pagani E, (1) ArcelliD, (1) Caporaso P, (3) Bondanza S, (4, 5) Di Leva G, (6,7) Ferracin M, (4, 5, 8) Volinia S, (2, 9) Bonmassar E, (4, 5) Croce CM, (1) D'Atri S. (literal)

Pagina inizio

• 393 (literal)

Pagina fine

• 400 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• I.F. = 2.447 Citations = 12 in Web of Knoledge Citations = 11 in Scopus (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 35(2) (literal)

Rivista

• International journal of oncology (Rivista)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Ist Dermopat Immacolata, IRCCS, Mol Oncol Lab, I-00167 Rome, Italy 2. CNR, Inst Neurobiol & Mol Med, Dept Med, I-00133 Rome, Italy 3. Ist Dermopat Immacolata, IRCCS, Lab Tissue Engn & Cutaneous Physiopathol, I-00167 Rome, Italy 4. Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA 5. Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA 6. Univ Ferrara, Dept Expt & Diagnost Med, I-44100 Ferrara, Italy 7. Univ Ferrara, Interdept Ctr Canc Res, I-44100 Ferrara, Italy 8. Univ Ferrara, DAMA, Dept Morphol & Embryol, I-44100 Ferrara, Italy 9. Univ Roma Tor Vergata, Dept Neurosci, Sch Med, I-00133 Rome, Italy (literal)

Titolo

• Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155 (literal)

Abstract

• Altered expression of microRNAs (miRNAs) has been detected in cancer, suggesting that these small non-coding RNAs can act as oncogenes or tumor suppressor genes. In the present study, we investigated the expression of miRNA-17-5p, miRNA-18a, miRNA-20a, miRNA-92a, miRNA-146a, miRNA-146b and miRNA-155 by real-time quantitative RT-PCR in a panel of melanocyte cultures and melanoma cell lines and explored the possible role of miRNA-155 in melanoma cell proliferation and survival. The analyzed miRNAs were selected on the basis of previous studies strongly supporting their involvement in cancer development and/or progression. We found that miRNA-17-5p, miRNA-18a, miRNA-20a, and miRNA-92a were overexpressed, whereas miRNA-146a, miRNA-146b and miRNA-155 were down-regulated in the majority of melanoma cell lines with respect to melanocytes. Ectopic expression of miRNA-155 significantly inhibited proliferation in 12 of 13 melanoma cell lines with reduced levels of this miRNA and induced apoptosis in 4 out of 4 cell lines analyzed. In conclusion, our data further support the finding of altered miRNA expression in melanoma cells and establish for the first time that miRNA-155 is a negative regulator of melanoma cell proliferation and survival. (literal)

Prodotto di

• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• ENZO BONMASSAR (Unità di personale esterno)
• ESTER ALVINO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)

Autore CNR di

• ESTER ALVINO (Unità di personale interno)
• ENZO BONMASSAR (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• International journal of oncology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155" (Insieme di parole chiave)