Axonal transport deficit in the optic nerve of rats with inherited retinitis pigmentosa and experimentally induced glaucoma (Articolo in rivista)

Type
Label
  • Axonal transport deficit in the optic nerve of rats with inherited retinitis pigmentosa and experimentally induced glaucoma (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Sposato V. 1, Iovieno A. 2, Sornelli F. 1, Aloe L. 1 (2008)
    Axonal transport deficit in the optic nerve of rats with inherited retinitis pigmentosa and experimentally induced glaucoma
    (literal)
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  • Sposato V. 1, Iovieno A. 2, Sornelli F. 1, Aloe L. 1 (literal)
Pagina inizio
  • 1553 (literal)
Pagina fine
  • 1558 (literal)
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  • Epub 2008 Aug 6 (literal)
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  • 246 (literal)
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  • Valentina Sposato and Alfonso Iovieno contributed equally to this work. (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1 - Section of Neurobiology, Institute of Neurobiology and Molecular Medicine, CNR, Via del Fosso di Fiorano, 64/65, I-00143 Rome, Italy 2 - Department of Ophthalmology, University of Rome “Campus Bio-Medico”, Rome, Italy (literal)
Titolo
  • Axonal transport deficit in the optic nerve of rats with inherited retinitis pigmentosa and experimentally induced glaucoma (literal)
Abstract
  • Background Aim of this study was to investigate the retrograde axonal transport from optic nerve (ON) to retinal ganglion cell (RGC) in two animal models: in Royal College of Surgeons (RCS) rats, a rat model for retinal degeneration, and in a rat model for glaucoma induced by elevated intraocular pressure (IOP). Methods To carry out this study, dextran tetramethylrhodamine (DTMR- an hydrophilic neurotracer dye) was injected into the ON; 24 hrs later, the retina was removed and the number of labeled RGCs of the experimental rats was counted and compared. Results The results of these studies showed that the number of fluorescent-labeled RGCs in RCS rats and in rats with elevated IOP was reduced compared to the number of labeled RGCs of their respective controls. Conclusion Our findings suggest that RCS rats are characterized not only by loss of photoreceptor cells but also by functional deficits of RGCs. (literal)
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