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Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates (Articolo in rivista)

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Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates (Articolo in rivista) (literal)

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Cirulli F. a), Francia N. a), Berry A. a), Aloe L. b), Alleva E. a), Suomi S.J. c) (2009)
Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates
in Neuroscience and biobehavioral reviews
(literal)

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Cirulli F. a), Francia N. a), Berry A. a), Aloe L. b), Alleva E. a), Suomi S.J. c) (literal)

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a) Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161 Rome, Italy b) Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy c) Laboratory of Comparative Ethology, National Institute of Child Health and Human Development (NICHD), Poolesville, MD, USA (literal)

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Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates (literal)

Abstract

Early adverse events can enhance stress responsiveness and lead to greater susceptibility for psychopathology at adulthood. The epigenetic factors involved in transducing specific features of the rearing environment into stable changes in brain and behavioural plasticity have only begun to be elucidated. Neurotrophic factors, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), are affected by stress and play a major role in brain development and in the trophism of specific neuronal networks involved in cognitive function and in mood disorders. In addition to the central nervous system, these effectors are produced by peripheral tissues, thus being in a position to integrate the response to external challenges. In this paper we will review data, obtained from animal models, indicating that early maternal deprivation stress can affect neurotrophin levels. Maladaptive or repeated activation of NGF and BDNF, early during postnatal life, may influence stress sensitivity at adulthood and increase vulnerability for stress-related psychopathology. (literal)

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