Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Sposato V. a), Bucci M.G. b), Coassin M. c), Russo M.A. d), Lambiase A. c), Aloe L. a) (2008)
  Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma
  in Neuroscience letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sposato V. a), Bucci M.G. b), Coassin M. c), Russo M.A. d), Lambiase A. c), Aloe L. a) (literal)

Pagina inizio

• 20 (literal)

Pagina fine

• 24 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Epub 2008 Sep 18 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 446/1 (literal)

Rivista

• Neuroscience letters (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a) Institute of Neurobiology and Molecular Medicine, Section of Neurobiology, National Research Council (CNR), Via del Fosso di Fiorano 64/65, I-00143 Rome, Italy b) IRCCS-Bietti Foundation, Rome, Italy c) Ophthalmology, University of Rome “Campus Bio-Medico”, Rome, Italy d) IRCCS San Raffaele Pisana, Rome, Italy (literal)

Titolo

• Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma (literal)

Abstract

• Glaucoma (GL) is an optic neuropathy characterized by progressive loss of visual field due to retinal cell death and optic nerve (ON) degeneration, usually in response to abnormal elevated intraocular pressure (EIOP). It has previously demonstrated that cells of the ON express nerve growth factor (NGF) and NGF-receptors. Relatively little is known, however, about their role on the ON of the glaucomatous eye. The aim of the study was to elucidate this aspect. Using a rat model of GL we investigated the response of NGF and NGF-receptors in the ON of subjects with experimentally induced EIOP. Our results show that EIOP significantly impairs the presence of NGF and NGF-receptor proteins and TrkA gene expression in the ON of glaucomatous eye. These findings suggest that NGF and NGF-receptor might be important signals for the ON response in the EIOP (literal)

Prodotto di

• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• LUIGI ALOE (Unità di personale interno)
• valentina sposato (Persona)

Insieme di parole chiave

• Parole chiave di "Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)

Autore CNR di

• LUIGI ALOE (Unità di personale interno)
• valentina sposato (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience letters (Rivista)

Insieme di parole chiave di

• Parole chiave di "Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma" (Insieme di parole chiave)