Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1093/cvr/cvp067 (literal)

Alternative label

• Gaetani R.1; Ledda M.2; Barile L.1; Chimenti I.1; De Carlo F.2; Forte E.1; Ionta V.1; Giuliani L.3; D'Emilia E.3; Frati G.1,4,5; Miraldi F.6; Pozzi D.1; Messina E.1; Grimaldi S.2; Giacomello A.1; Lisi A.2 (2009)
  Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields
  in Cardiovascular research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gaetani R.1; Ledda M.2; Barile L.1; Chimenti I.1; De Carlo F.2; Forte E.1; Ionta V.1; Giuliani L.3; D'Emilia E.3; Frati G.1,4,5; Miraldi F.6; Pozzi D.1; Messina E.1; Grimaldi S.2; Giacomello A.1; Lisi A.2 (literal)

Pagina inizio

• 411 (literal)

Pagina fine

• 420 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor= 5.947 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 82 (literal)

Rivista

• Cardiovascular research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Department of Experimental Medicine, Pasteur Institute, Cenci Bolognetti Foundation, ‘Sapienza’ University of Rome, viale Regina Elena 324, 00161 Rome, Italy; 2 Institute of Neurobiology and Molecular Medicine, CNR, via Fosso del Cavaliere 100 00133, Rome, Italy; 3 ISPESL-DIPIA, Rome, Italy; 4 Department of Cardiac Surgery, ‘Sapienza’ University of Rome, Polo Pontino-ICOT, Latina 04100, Italy; 5 I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy; 6 Department of Heart and Great Vessels ‘Attilio Reale’, ‘Sapienza’ University of Rome, viale Regina Elena 324, 00161 Rome, Italy (literal)

Titolo

• Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields (literal)

Abstract

• Aims: Modulation of cardiac stem cell (CSC) differentiation with minimal manipulation is one of the main goals of clinical applicability of cell therapy for heart failure. CSCs, obtained from human myocardial bioptic specimens and grown as cardiospheres (CSps) and cardiosphere-derived cells (CDCs), can engraft and partially regenerate the infarcted myocardium, as previously described. In this paper we assessed the hypothesis that exposure of CSps and CDCs to extremely low-frequency electromagnetic fields (ELF-EMFs), tuned at Ca2+ ion cyclotron energy resonance (Ca2+-ICR), may drive their differentiation towards a cardiac-specific phenotype. Methods and results: A significant increase in the expression of cardiac markers was observed after 5 days of exposure to Ca2+-ICR in both human CSps and CDCs, as evidenced at transcriptional, translational, and phenotypical levels. Ca2+ mobilization among intracellular storages was observed and confirmed by compartmentalized analysis of Ca2+ fluorescent probes. Conclusions: These results suggest that ELF-EMFs tuned at Ca2+-ICR could be used to drive cardiac-specific differentiation in adult cardiac progenitor cells without any pharmacological or genetic manipulation of the cells that will be used for therapeutic purposes. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Interazione tra frequenze di risonanza di ciclotrone di ioni e biosistemi (ME.P06.012.003) (Modulo)
• Studio dell'interazione tra campi elettromagnetici e cellule eucariotiche (ME.P06.012.001) (Modulo)

Autore CNR

• ANTONELLA LISI (Unità di personale interno)
• SETTIMIO GRIMALDI (Persona)
• MARIO LEDDA (Persona)

Insieme di parole chiave

• Parole chiave di "Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANTONELLA LISI (Unità di personale interno)
• MARIO LEDDA (Persona)
• SETTIMIO GRIMALDI (Persona)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Studio dell'interazione tra campi elettromagnetici e cellule eucariotiche (ME.P06.012.001) (Modulo)
• Interazione tra frequenze di risonanza di ciclotrone di ioni e biosistemi (ME.P06.012.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cardiovascular research (Rivista)

Insieme di parole chiave di

• Parole chiave di "Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields" (Insieme di parole chiave)