NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons (Articolo in rivista)

Type
Label
  • NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.0904998106 (literal)
Alternative label
  • Matrone C., Ciotti M.T., Mercanti D., Marolda R., Calissano P. (2008)
    NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Matrone C., Ciotti M.T., Mercanti D., Marolda R., Calissano P. (literal)
Pagina inizio
  • 13139 (literal)
Pagina fine
  • 13144 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699376/ (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 105 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Vol. 105(35); Epub 2008 Aug 26 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 27 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • MERCANTI Delio = Istituto di Neurobiologia e Medicina Molecolare (INMM) - Ora Istituto di Biologia Cellulare e Neurobiologia (IBCN) (literal)
Titolo
  • NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons (literal)
Abstract
  • Here, we report that interruption of NGF or BDNF signaling in hippocampal neurons rapidly activates the amyloidogenic pathway and causes neuronal apoptotic death. These events are associated with an early intracellular accumulation of PS1 N-terminal catalytic subunits and of APP C-terminal fragments and a progressive accumulation of intra- and extracellular Abeta aggregates partly released into the culture medium. The released pool of Abeta induces an increase of APP and PS1 holoprotein levels, creating a feed-forward toxic loop that might also cause the death of healthy neurons. These events are mimicked by exogenously added Abeta and are prevented by exposure to beta- and gamma-secretase inhibitors and by antibodies directed against Abeta peptides. The same cultured neurons deprived of serum die, but APP and PS1 overexpression does not occur, Abeta production is undetectable, and cell death is not inhibited by anti-Abeta antibodies, suggesting that hippocampal amyloidogenesis is not a simple consequence of an apoptotic trigger but is due to interruption of neurotrophic signaling. (literal)
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