Interactions of pyridinecarboxylic acid chelators with brain metal ions: Cu(II), Zn(II), and Al(III) (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Interactions of pyridinecarboxylic acid chelators with brain metal ions: Cu(II), Zn(II), and Al(III) (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Sija E., Dean A., Jakusch T., Di Marco V, B., Venzo A., Kiss T. (2011)
  Interactions of pyridinecarboxylic acid chelators with brain metal ions: Cu(II), Zn(II), and Al(III)
  
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sija E., Dean A., Jakusch T., Di Marco V, B., Venzo A., Kiss T. (literal)

Pagina inizio

• 399 (literal)

Pagina fine

• 419 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• DOI: 10.1007/s00706-011-0482-x (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 142 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• pubblicazione scientifica (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Inorganic and Analytical Chemistry, University of Szeged, P.O. Box 440, Szeged 6701, Hungary Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padua, Italy Institute of Science and Molecular Technologies, CNR, via Marzolo 1, 35131 Padua, Italy HAS-USZ Bioinorganic Research Group, P.O. Box 440, Szeged 6701, Hungary (literal)

Titolo

• Interactions of pyridinecarboxylic acid chelators with brain metal ions: Cu(II), Zn(II), and Al(III) (literal)

Abstract

• The interactions of Cu(II), Zn(II), and Al(III) with 1,6-dimethyl-4-hydroxy-3-pyridinecarboxylic acid (DQ716) and 2,6-dimethyl-3-hydroxy-4-pyridinecarboxylic acid (DT726), possible chelating agents in Alzheimer’s disease, were investigated in aqueous solution. The proton dissociation constants of the ligands, the stability constants, and the coordination modes of the metal complexes formed were determined by pH-potentiometric, UV–vis spectrophotometric, and 1H NMR methods. The nitrogen of the pyridine ring changes the proton affinity of the carboxylate and phenolate moieties and these pyridine derivatives form stronger complexes with Cu(II), Zn(II), and Al(III) than salicylic acid. Interactions of the ligands with human serum albumin as their potential transporter in blood were investigated at physiological pH through ultrafiltration by UV–vis and fluorescence spectroscopy. (literal)

Prodotto di

• Nanoingegneria chimica di sistemi assemblati mediante interazioni intermolecolari specifiche (PM.P07.002.002) (Modulo)
• Istituto di Chimica della Materia Condensata e di Tecnologie per l'Energia (ICMATE) (Istituto)
• Institute of molecular science and technologies (ISTM) (Istituto)

Autore CNR

• ALFONSO VENZO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular science and technologies (ISTM) (Istituto)
• Istituto di Chimica della Materia Condensata e di Tecnologie per l'Energia (ICMATE) (Istituto)
• Nanoingegneria chimica di sistemi assemblati mediante interazioni intermolecolari specifiche (PM.P07.002.002) (Modulo)

Autore CNR di

• ALFONSO VENZO (Unità di personale interno)