http://www.cnr.it/ontology/cnr/individuo/prodotto/ID48699
Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation (Articolo in rivista)
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- Label
- Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Alternative label
Dalla Via L., Santi S., Di Noto V., Venzo A., Agostinelli E., Calcabrini A., Condello M, Toninello A. (2011)
Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation
(literal)
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- Dalla Via L., Santi S., Di Noto V., Venzo A., Agostinelli E., Calcabrini A., Condello M, Toninello A. (literal)
- Pagina inizio
- Pagina fine
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- DOI 10.1007/s00775-011-0771-1 (literal)
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- pubblicazione scientifica (literal)
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- ISI Web of Science (WOS) (literal)
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- Department of Pharmaceutical Sciences, University of Padova, Via F. Marzolo, 5, 35131 Padua, Italy
Department of Chemical Sciences, University of Padova, Via F. Marzolo, 1, 35131 Padua, Italy
CNR-ISTM, Institute of Molecular Sciences and Technologies, Via F. Marzolo, 1, 35131 Padua, Italy
Department of Biochemical Sciences, Institute of Molecular Biology and Pathology, University of Rome La Sapienza and CNR, Rome, Italy
Department of Technology and Health, Italian National Institute of Health,
Viale Regina Elena 299, 00161 Rome, Italy
Department of Biological Chemistry, University of Padova, Via G. Colombo, 3, 35121 Padua, Italy (literal)
- Titolo
- Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation (literal)
- Abstract
- Four platinum(II) complexes of general formula [PtCl(g1-C9H7)L2] [where L2 is 1,2-bis(diphenylphosphino) ethane (dppe) 1 or cycloocta-1,5-diene (cod) 3] and [PtCl2L2] (where L2 is dppe 2 or cod 4) were studied. Inhibition growth assays on human tumor cell lines evidenced for 1 and 3 an antiproliferative effect and, interestingly, the cytotoxic effect exerted by 1 is similar to that of cisplatin. Electrochemical and NMR measurements
allowed us to determine the structural and redox properties. Investigation of the mechanism of action responsible for the cytotoxicity demonstrated a weak capacity of interacting with DNA. Some experiments performed on rat liver mitochondria indicate that 1 acts as an inducer of the mitochondrial permeability transition, thus leading to the release of proapoptotic factors, such as cytochrome c and apoptosis-inducing factor (literal)
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