Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Dalla Via L., Santi S., Di Noto V., Venzo A., Agostinelli E., Calcabrini A., Condello M, Toninello A. (2011)
  Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation
  
  (literal)

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• Dalla Via L., Santi S., Di Noto V., Venzo A., Agostinelli E., Calcabrini A., Condello M, Toninello A. (literal)

Pagina inizio

• 695 (literal)

Pagina fine

• 713 (literal)

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• DOI 10.1007/s00775-011-0771-1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 16 (literal)

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• pubblicazione scientifica (literal)

Note

• ISI Web of Science (WOS) (literal)

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• Department of Pharmaceutical Sciences, University of Padova, Via F. Marzolo, 5, 35131 Padua, Italy Department of Chemical Sciences, University of Padova, Via F. Marzolo, 1, 35131 Padua, Italy CNR-ISTM, Institute of Molecular Sciences and Technologies, Via F. Marzolo, 1, 35131 Padua, Italy Department of Biochemical Sciences, Institute of Molecular Biology and Pathology, University of Rome ‘‘La Sapienza’’ and CNR, Rome, Italy Department of Technology and Health, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy Department of Biological Chemistry, University of Padova, Via G. Colombo, 3, 35121 Padua, Italy (literal)

Titolo

• Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation (literal)

Abstract

• Four platinum(II) complexes of general formula [PtCl(g1-C9H7)L2] [where L2 is 1,2-bis(diphenylphosphino) ethane (dppe) 1 or cycloocta-1,5-diene (cod) 3] and [PtCl2L2] (where L2 is dppe 2 or cod 4) were studied. Inhibition growth assays on human tumor cell lines evidenced for 1 and 3 an antiproliferative effect and, interestingly, the cytotoxic effect exerted by 1 is similar to that of cisplatin. Electrochemical and NMR measurements allowed us to determine the structural and redox properties. Investigation of the mechanism of action responsible for the cytotoxicity demonstrated a weak capacity of interacting with DNA. Some experiments performed on rat liver mitochondria indicate that 1 acts as an inducer of the mitochondrial permeability transition, thus leading to the release of proapoptotic factors, such as cytochrome c and apoptosis-inducing factor (literal)

Prodotto di

• Institute of molecular science and technologies (ISTM) (Istituto)
• Istituto di Chimica della Materia Condensata e di Tecnologie per l'Energia (ICMATE) (Istituto)
• Nanoingegneria chimica di sistemi assemblati mediante interazioni intermolecolari specifiche (PM.P07.002.002) (Modulo)

Autore CNR

• ALFONSO VENZO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular science and technologies (ISTM) (Istituto)
• Istituto di Chimica della Materia Condensata e di Tecnologie per l'Energia (ICMATE) (Istituto)
• Nanoingegneria chimica di sistemi assemblati mediante interazioni intermolecolari specifiche (PM.P07.002.002) (Modulo)

Autore CNR di

• ALFONSO VENZO (Unità di personale interno)