Water-Dispersible Sugar-Coated Iron Oxide Nanoparticles. An Evaluation of their Relaxometric and Magnetic Hyperthermia Properties (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Water-Dispersible Sugar-Coated Iron Oxide Nanoparticles. An Evaluation of their Relaxometric and Magnetic Hyperthermia Properties (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Lartigue, Lernaic; Innocenti, Claudia; Kalaivani, Thangavel; Awwad, Azzam; Lascialfari, Alessandro; Duque, Maria del Mar Sanchez; Guari, Yannick; Larinova, Joulia; Guerin, Christian; Montero, Jean-Louis Georges; Barragan-Montero, Veronique; Arosio, Paolo; (2011)
  Water-Dispersible Sugar-Coated Iron Oxide Nanoparticles. An Evaluation of their Relaxometric and Magnetic Hyperthermia Properties
  in Journal of the American Chemical Society (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Lartigue, Lernaic; Innocenti, Claudia; Kalaivani, Thangavel; Awwad, Azzam; Lascialfari, Alessandro; Duque, Maria del Mar Sanchez; Guari, Yannick; Larinova, Joulia; Guerin, Christian; Montero, Jean-Louis Georges; Barragan-Montero, Veronique; Arosio, Paolo; (literal)

Pagina inizio

• 10459 (literal)

Pagina fine

• 10472 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 133 (literal)

Rivista

• Journal of the American Chemical Society (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• 10.1007/s00339-011-6359-3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• [Lartigue, Lernaic; Duque, Maria del Mar Sanchez; Guari, Yannick; Larinova, Joulia; Guerin, Christian] Univ Montpellier 2, Inst Charles Gerhardt Montpellier, CNRS, UMR Chim Mol & Org Solide 5253, F-34095 Montpellier 5, France. [Lartigue, Lernaic; Innocenti, Claudia; Gatteschi, Dante; Sangregorio, Claudio] Univ Firenze, Dipartimento Chim, I-50019 Sesto Fno Firenze, Italy; INSTM Res Unit, I-50019 Sesto Fno Firenze, Italy. [Kalaivani, Thangavel; Arosio, Paolo; Lascialfari, Alessandro] Univ Milan, Dipartimento Sci Mol Applicate Biosistemi, I-20134 Milan, Italy; Consorzio INSTM, Milano Unit, I-20134 Milan, Italy. [Kalaivani, Thangavel; Lascialfari, Alessandro] CNR, Ist Nanosci, Ctr S3, I-41125 Modena, Italy. [Awwad, Azzam; Montero, Jean-Louis Georges; Barragan-Montero, Veronique] Ecole Natl Super Chim Montpellier, Equipe SyGReM, Inst Biomol Max Mousseron, UMR. 5247,CNRS UM1 UM2, F-34296 Montpellier, France. [Lascialfari, Alessandro] Univ Pavia, Dipartimento Fis A Volta, I-27100 Pavia, Italy. [Sangregorio, Claudio] CNR ISTM, I-23310 Milan, Italy. (literal)

Titolo

• Water-Dispersible Sugar-Coated Iron Oxide Nanoparticles. An Evaluation of their Relaxometric and Magnetic Hyperthermia Properties (literal)

Abstract

• Synthesis of functionalized magnetic nanoparticles (NPs) for biomedical applications represents a current challenge. In this paper we present the synthesis and characterization of water-dispersible sugar-coated iron oxide NPs specifically designed as magnetic fluid hyperthermia heat mediators and negative contrast agents for magnetic resonance imaging. In particular, the influence of the inorganic core size was investigated. To this end, iron oxide NPs with average size in the range of 4-35 nm were prepared by thermal decomposition of molecular precursors and then coated with organic ligands bearing a phosphonate group on one side and rhamnose, mannose, or ribose moieties on the other side. In this way a strong anchorage of the organic ligand on the inorganic surface was simply realized by ligand exchange, due to covalent bonding between the Fe(3+) atom and the phosphonate group. These synthesized nanoobjects can be fully dispersed in water forming colloids that are stable over very long periods. Mannose, ribose, and rhamnose were chosen to test the versatility of the method and also because these carbohydrates, in particular rhamnose, which is a substrate of skin lectin, confer targeting properties to the nanosystems. The magnetic, hyperthermal, and relaxometric properties of all the synthesized samples were investigated. Iron oxide NPs of ca. 16-18 inn were found to represent an efficient bifunctional targeting system for theranostic applications, as they have very good transverse relaxivity (three times larger than the best currently available commercial products) and large heat release upon application of radio frequency (RF) electromagnetic radiation with amplitude and frequency close to the human tolerance limit. The results have been rationalized on the basis of the magnetic properties of the investigated samples. (literal)

Prodotto di

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Nanosistemi organizzati di magneti molecolari (PM.P05.012.001) (Modulo)

Autore CNR

• CLAUDIO SANGREGORIO (Unità di personale interno)
• ALESSANDRO LASCIALFARI (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Water-Dispersible Sugar-Coated Iron Oxide Nanoparticles. An Evaluation of their Relaxometric and Magnetic Hyperthermia Properties" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Nanosistemi organizzati di magneti molecolari (PM.P05.012.001) (Modulo)

Autore CNR di

• ALESSANDRO LASCIALFARI (Unità di personale esterno)
• CLAUDIO SANGREGORIO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of the American Chemical Society (Rivista)

Insieme di parole chiave di

• Keywords of "Water-Dispersible Sugar-Coated Iron Oxide Nanoparticles. An Evaluation of their Relaxometric and Magnetic Hyperthermia Properties" (Insieme di parole chiave)